QuickView for CCN2 (gene)

Gene Symbol:

CTGF Homo sapiens

Full name:

connective tissue growth factor

Synonyms:

CCN2, HCS24, IGFBP8, NOV2, connective tissue growth factor, CCN family member 2, IBP-8, IGF-binding protein 8, IGFBP-8, hypertrophic chondrocyte-specific protein 24, insulin-like growth factor-binding protein 8

Genomic Location:

Chr 6: 132311009-132314211

Description:

The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic s...

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The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Bos taurus ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  PR_Q2 ,  RTAAACA_FREAC2_01 ,  FREAC7_01 ,  TTTGCAC_MIR19A_MIR19B ,  MZF1_01 ,  YTATTTTNR_MEF2_02 ,  ARP1_01 ,  AREB6_04 ,  NFKAPPAB_01 ,  GGGAGGRR_MAZ_Q6 ,  MEF2_02 ,  TATAAA_TATA_01 ,  CDPCR3HD_01 ,  STAT3_02 ,  GCACCTT_MIR18A_MIR18B ,  LFA1_Q6 ,  PXR_Q2 ,  HNF4_Q6 ,  SRF_Q4 ,  TGTTTGY_HNF3_Q6 ,  AHRARNT_01 ,  WGGAATGY_TEF1_Q6 ,  CEBP_C ,  IK2_01 ,  CREL_01 ,  GRE_C ,  NFKB_Q6 ,  NFKB_C ,  ACACTGG_MIR199A_MIR199B

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-143 ,  Predicted Gene Targets for miR-18 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-199 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-485-5p ,  Predicted Gene Targets for miR-149 ,  Predicted Gene Targets for miR-375

miRNA binding sites
(Source: miRecords):

hsa-miR-124 Targeted Genes

Cytogenetic Map:

6q23.2

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