QuickView for CCND2 (gene)

Gene Symbol:

CCND2 Homo sapiens

Full name:

cyclin D2

Synonyms:

KIAK0002, MPPH3, G1/S-specific cyclin-D2

Genomic Location:

Chr 12: 4253199-4284777

Description:

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of ...

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The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK4 or CDK6 and functions as a regulatory subunit of the complex, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. Mutations in this gene are associated with megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3).

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Gallus gallus ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

PBX1_02 ,  TTTGCAC_MIR19A_MIR19B ,  AAGCCAT_MIR135A_MIR135B ,  FOX_Q2 ,  EFC_Q6 ,  MIF1_01 ,  TTCCGTT_MIR191 ,  GCANCTGNY_MYOD_Q6 ,  AGCACTT_MIR93_MIR302A_MIR302B_MIR302C_MIR302D_MIR372_MIR373_MIR520E_MIR520A_MIR526B_MIR520B_MIR520C_MIR520D ,  CIZ_01 ,  TACTTGA_MIR26A_MIR26B ,  CGCTGCT_MIR503 ,  TAGCTTT_MIR9 ,  PBX1_01 ,  MYB_Q5_01 ,  GCCATNTTG_YY1_Q6 ,  CREB_Q3 ,  HEB_Q6 ,  GGGAGGRR_MAZ_Q6 ,  CREBP1_Q2 ,  TFIII_Q6 ,  CEBPDELTA_Q6 ,  CDP_02 ,  GTGACGY_E4F1_Q6 ,  TEF1_Q6 ,  ATACCTC_MIR202 ,  TGCCTTA_MIR124A ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  TGCTGAY_UNKNOWN ,  CEBPB_02 ,  ATGTTTC_MIR494 ,  NKX61_01 ,  E47_01 ,  SPZ1_01 ,  STAT_01 ,  RNGTGGGC_UNKNOWN ,  GTGCCTT_MIR506 ,  YTAAYNGCT_UNKNOWN ,  AP4_Q6_01 ,  SCGGAAGY_ELK1_02 ,  TTCYNRGAA_STAT5B_01 ,  AAGCACT_MIR520F ,  CAGCTG_AP4_Q5 ,  TGGTGCT_MIR29A_MIR29B_MIR29C ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  HNF1_Q6 ,  HIF1_Q3 ,  ACCATTT_MIR522 ,  CREB_Q2_01 ,  HNF6_Q6 ,  CACTTTG_MIR520G_MIR520H ,  GGGNNTTTCC_NFKB_Q6_01 ,  GGGTGGRR_PAX4_03 ,  TAXCREB_01 ,  LMO2COM_01 ,  STAT5A_02 ,  TCF11_01 ,  LBP1_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for let-7 ,  Predicted Gene Targets for miR-1 ,  Predicted Gene Targets for miR-135 ,  Predicted Gene Targets for miR-145 ,  Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-153 ,  Predicted Gene Targets for miR-183 ,  Predicted Gene Targets for miR-186 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-191 ,  Predicted Gene Targets for miR-196 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-299 ,  Predicted Gene Targets for miR-320 ,  Predicted Gene Targets for miR-448 ,  Predicted Gene Targets for miR-494 ,  Predicted Gene Targets for miR-503 ,  Predicted Gene Targets for miR-93 ,  Predicted Gene Targets for miR-96 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-182 ,  Predicted Gene Targets for miR-29 ,  Predicted Gene Targets for miR-486

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Cytogenetic Map:

12p13.32

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