QuickView for CCNE2;jsessionid=546F649770729EDEECC87F580F6DE192 (gene)

Gene Symbol:

CCNE2 Homo sapiens

Full name:

cyclin E2

Synonyms:

CYCE2, G1/S-specific cyclin-E2

Genomic Location:

Chr 8: 95961628-95976660

Description:

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of ...

View Full Description

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2. This cyclin has been shown to specifically interact with CIP/KIP family of CDK inhibitors, and plays a role in cell cycle G1/S transition. The expression of this gene peaks at the G1-S phase and exhibits a pattern of tissue specificity distinct from that of cyclin E1. A significantly increased expression level of this gene was observed in tumor-derived cells.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GTATTAT_MIR3693P ,  CACTGCC_MIR34A_MIR34C_MIR449 ,  GCANCTGNY_MYOD_Q6 ,  CAGTGTT_MIR141_MIR200A ,  TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P ,  GTGCAAT_MIR25_MIR32_MIR92_MIR363_MIR367 ,  GGGAGGRR_MAZ_Q6 ,  ACCAAAG_MIR9 ,  ATACTGT_MIR144 ,  AP4_Q6_01 ,  GTGTCAA_MIR514 ,  HEN1_02 ,  CTGCAGY_UNKNOWN ,  CTTTGT_LEF1_Q2 ,  CAGCTG_AP4_Q5 ,  GCTNWTTGK_UNKNOWN ,  TATTATA_MIR374

View More

View Less

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-144 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-141 ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-34 ,  Predicted Gene Targets for miR-369-3p ,  Predicted Gene Targets for miR-494 ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-374 ,  Predicted Gene Targets for miR-410

View More

View Less

Cytogenetic Map:

8q22.1

search → result