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QuickView for CD109 (gene)


Gene Symbol:
CD109 Homo sapiens Homo sapiens
Full name:
CD109 molecule
Synonyms:
CPAMD7, p180, r150, CD109 antigen, 150 kDa TGF-beta-1-binding protein, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7, Gov platelet alloantigens, activated T-cell marker CD109, platelet-specific Gov antigen
Genomic Location:
Chr 6: 74462235-74594761
Description:
This gene encodes a glycosyl phosphatidylinositol (GPI)-linked glycoprotein that localizes to the surface of platelets, activated T-cells, and endothelial cells. The protein binds to and negatively regulates signalling by transforming growth factor beta (TGF-beta). Multiple transcript variants encoding different isoforms have been found for this ge...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Macaca mulatta Danio rerio Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 6
6q13





GO Molecular Function

transforming growth factor beta binding | endopeptidase inhibitor activity | cytokine binding | enzyme inhibitor activity | growth factor binding | molecular function regulator | protein binding | serine-type endopeptidase inhibitor activity | peptidase inhibitor activity | enzyme regulator activity

GO Biological Process

negative regulation of phosphorylation | molting cycle | endopeptidase inhibitor activity | exocytosis | syncytium formation by plasma membrane fusion | establishment of localization | myeloid cell differentiation | platelet degranulation | regulation of transforming growth factor beta receptor signaling pathway | negative regulation of cellular process | cell differentiation | negative regulation of protein phosphorylation | negative regulation of proteolysis | cellular process | secretion | localization | negative regulation of signaling | immune system development | regulation of proteolysis | negative regulation of keratinocyte proliferation | negative regulation of cellular metabolic process | tissue development | regulation of cell differentiation | negative regulation of wound healing | regulation of cellular process | regulation of metabolic process | epithelium development | regulation of keratinocyte proliferation | enzyme inhibitor activity | regulation of cell proliferation | regulation of epithelial cell differentiation | secretion by cell | negative regulation of metabolic process | hemopoiesis | regulation of wound healing | negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | molecular function regulator | negative regulation of cellular response to transforming growth factor beta stimulus | leukocyte differentiation | system development | regulation of signal transduction | negative regulation of phosphate metabolic process | multicellular organism development | negative regulation of catalytic activity | syncytium formation | regulation of peptidase activity | regulation of catalytic activity | regulation of phosphorylation | negative regulation of peptidase activity | osteoclast differentiation | regulation of epidermis development | myeloid leukocyte differentiation | regulation of keratinocyte differentiation | regulation of nitrogen compound metabolic process | negative regulation of cellular response to growth factor stimulus | vesicle-mediated transport | regulation of cellular protein metabolic process | regulated exocytosis | epidermis development | skin development | osteoclast fusion | negative regulation of response to wounding | regulation of cellular metabolic process | regulation of protein metabolic process | regulation of protein phosphorylation | regulation of cellular response to growth factor stimulus | negative regulation of epithelial cell proliferation | negative regulation of transforming growth factor beta receptor signaling pathway | hair cycle | anatomical structure development | multinuclear osteoclast differentiation | hair cycle process | animal organ development | negative regulation of cellular protein metabolic process | skin epidermis development | regulation of phosphate metabolic process | serine-type endopeptidase inhibitor activity | anatomical structure formation involved in morphogenesis | negative regulation of protein metabolic process | regulation of response to wounding | regulation of cell communication | negative regulation of molecular function | negative regulation of signal transduction | regulation of epithelial cell proliferation | peptidase inhibitor activity | enzyme regulator activity | anatomical structure morphogenesis | regulation of endopeptidase activity | regulation of developmental process | developmental process | negative regulation of cell proliferation | negative regulation of hydrolase activity | immune system process | hematopoietic or lymphoid organ development | regulation of epidermal cell differentiation | hair follicle development | regulation of signaling | negative regulation of endopeptidase activity | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

secretory granule | organelle membrane | cytoplasmic vesicle | platelet alpha granule membrane | cell | intrinsic component of membrane | cytoplasm | intracellular organelle | platelet alpha granule | secretory granule membrane | secretory vesicle | endomembrane system | plasma membrane | vesicle | anchored component of membrane | extracellular region | membrane-bounded organelle | organelle | vesicle membrane | extracellular space | cell periphery | intracellular vesicle | cell surface | intracellular | membrane | cytoplasmic vesicle membrane