QuickView for CD117 (gene)

Gene Symbol:

KIT Homo sapiens

Full name:

KIT proto-oncogene receptor tyrosine kinase

Synonyms:

C-Kit, CD117, PBT, SCFR, mast/stem cell growth factor receptor Kit, c-Kit protooncogene, p145 c-kit, piebald trait protein, proto-oncogene c-Kit, proto-oncogene tyrosine-protein kinase Kit, soluble KIT variant 1, tyrosine-protein kinase Kit, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein

Genomic Location:

Chr 4: 55218852-55301638

Description:

This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors,...

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This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Danio rerio ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TTTGCAC_MIR19A_MIR19B ,  TCANNTGAY_SREBP1_01 ,  NKX3A_01 ,  CIZ_01 ,  ACTTTAT_MIR1425P ,  TTGCACT_MIR130A_MIR301_MIR130B ,  MYCMAX_B ,  GCACCTT_MIR18A_MIR18B ,  CAGGTG_E12_Q6 ,  YY1_01 ,  TGCCAAR_NF1_Q6 ,  GGCCAGT_MIR193A_MIR193B ,  CTTTGT_LEF1_Q2 ,  AACTTT_UNKNOWN ,  CEBPGAMMA_Q6 ,  AAGCACA_MIR218

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-130 ,  Predicted Gene Targets for miR-142-5p ,  Predicted Gene Targets for miR-18 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-193 ,  Predicted Gene Targets for miR-205 ,  Predicted Gene Targets for miR-218 ,  Predicted Gene Targets for miR-151

miRNA binding sites
(Source: miRecords):

hsa-miR-221 Targeted Genes ,  hsa-miR-222 Targeted Genes

Cytogenetic Map:

4q12

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