QuickView for CD131 (gene)
- Gene Symbol:
- CSF2RB
Homo sapiens - Full name:
- colony stimulating factor 2 receptor beta common subunit
- Synonyms:
- CD131, CDw131, IL3RB, IL5RB, SMDP5, betaGMR, cytokine receptor common subunit beta, GM-CSF/IL-3/IL-5 receptor common beta subunit, GM-CSF/IL-3/IL-5 receptor common beta-chain, beta common cytokine receptor, beta-GM-CSF receptor, colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage), colony-stimulating factor-2 receptor, beta, low-affinity, interleukin 3 receptor/granulocyte-macrophage colony stimulating factor 3 receptor, beta (high affinity)
- Genomic Location:
- Chr 22: 35648168-35664764
- Description:
-
The protein encoded by this gene is the common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defects in this gene have been reported to be associated with protein alveolar proteinosis (PAP).
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Danio rerio , Pan troglodytes , Canis lupus familiaris , Bos taurus , Gallus gallus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
22q12.3
GO Molecular Function
guanyl-nucleotide exchange factor activity | GTPase binding | interleukin-5 receptor activity | transmembrane signaling receptor activity | enzyme binding | Ras GTPase binding | molecular function regulator | catalytic activity | interleukin-3 receptor activity | signaling receptor activity | cytokine receptor activity | protein tyrosine kinase activity | protein binding | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | Ras guanyl-nucleotide exchange factor activity | protein kinase activity | transferase activity | small GTPase binding | kinase activity
GO Biological Process
respiratory gaseous exchange | guanyl-nucleotide exchange factor activity | response to cytokine | response to lipopolysaccharide | intracellular signal transduction | peptidyl-amino acid modification | peptidyl-tyrosine phosphorylation | interleukin-5 receptor activity | cellular response to interleukin-3 | cellular process | interleukin-3-mediated signaling pathway | regulation of cellular process | MAPK cascade | response to stimulus | signal transduction by protein phosphorylation | response to molecule of bacterial origin | protein modification process | macromolecule modification | molecular function regulator | response to external biotic stimulus | nitrogen compound metabolic process | phosphorus metabolic process | interleukin-5-mediated signaling pathway | response to lipid | interleukin-3 receptor activity | cytokine-mediated signaling pathway | cellular response to cytokine stimulus | phosphorylation | protein phosphorylation | phosphate-containing compound metabolic process | cytokine receptor activity | response to bacterium | cell communication | protein tyrosine kinase activity | protein metabolic process | response to organic substance | cell surface receptor signaling pathway | metabolic process | Ras guanyl-nucleotide exchange factor activity | protein kinase activity | organic substance metabolic process | signaling | cellular protein metabolic process | response to biotic stimulus | kinase activity | cellular protein modification process | cellular metabolic process | cellular response to organic substance | response to other organism | signal transduction | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
integral component of membrane | cell | plasma membrane protein complex | intrinsic component of membrane | receptor complex | granulocyte macrophage colony-stimulating factor receptor complex | protein-containing complex | plasma membrane | integral component of plasma membrane | cell periphery | intracellular | membrane | intrinsic component of plasma membrane
