QuickView for CD13 (gene)

Gene Symbol:

ANPEP Homo sapiens

Full name:

alanyl aminopeptidase, membrane

Synonyms:

APN, CD13, GP150, LAP1, P150, PEPN, aminopeptidase N, AP-M, AP-N, alanyl (membrane) aminopeptidase, aminopeptidase M, hAPN, membrane alanyl aminopeptidase, microsomal aminopeptidase, myeloid plasma membrane glycoprotein CD13

Genomic Location:

Chr 15: 88129130-88159076

Description:

Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell ty...

View Full Description

Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

HNF4ALPHA_Q6 ,  HNF1_01 ,  HP1SITEFACTOR_Q6 ,  TGACCTY_ERR1_Q2 ,  CTCAGGG_MIR125B_MIR125A ,  CTGCAGY_UNKNOWN ,  HNF1_Q6

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-125 ,  Predicted Gene Targets for miR-496

Cytogenetic Map:

15q26.1

search → result