QuickView for CD143 (gene)

Gene Symbol:

ACE Homo sapiens

Full name:

angiotensin I converting enzyme

Synonyms:

ACE1, CD143, DCP, DCP1, angiotensin-converting enzyme, CD143 antigen, angiotensin I converting enzyme (peptidyl-dipeptidase A) 1, angiotensin converting enzyme, somatic isoform, carboxycathepsin, dipeptidyl carboxypeptidase 1, dipeptidyl carboxypeptidase I, kininase II, peptidase P

Genomic Location:

Chr 17: 58908166-58928711

Description:

This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies hav...

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This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form, respectively, that are equally active.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Gallus gallus ,  Pan troglodytes ,  Danio rerio ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

HEN1_01 ,  NGFIC_01 ,  AGGAGTG_MIR483 ,  TATAAA_TATA_01 ,  CEBPDELTA_Q6 ,  ATCATGA_MIR433 ,  GGGGCCC_MIR296 ,  SP1_Q4_01 ,  EGR_Q6 ,  GTGCCAA_MIR96 ,  AAAGACA_MIR511 ,  SP1_Q6 ,  EGR1_01 ,  CAGCTG_AP4_Q5 ,  SP1_Q6_01 ,  SP1_Q2_01 ,  CTCCAAG_MIR432

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-192 ,  Predicted Gene Targets for miR-199 ,  Predicted Gene Targets for miR-433-3p ,  Predicted Gene Targets for miR-7 ,  Predicted Gene Targets for miR-96

Cytogenetic Map:

17q23.3

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