QuickView for CD167 (gene)

Gene Symbol:

DDR1 Homo sapiens

Full name:

discoidin domain receptor tyrosine kinase 1

Synonyms:

CAK, CD167, DDR, EDDR1, HGK2, MCK10, NEP, NTRK4, PTK3, PTK3A, RTK6, TRKE, epithelial discoidin domain-containing receptor 1, CD167 antigen-like family member A, PTK3A protein tyrosine kinase 3A, cell adhesion kinase, mammary carcinoma kinase 10, neuroepithelial tyrosine kinase, neurotrophic tyrosine kinase, receptor, type 4, protein-tyrosine kinase RTK-6, tyrosine kinase DDR, tyrosine-protein kinase CAK

Genomic Location:

Chr 6: 30959840-30975912

Description:

Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their ...

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Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

NKX25_01 ,  TGANTCA_AP1_C ,  TCANNTGAY_SREBP1_01 ,  AREB6_02 ,  SREBP1_02 ,  NFKAPPAB_01 ,  SREBP1_Q6 ,  STAT1_03 ,  AP2ALPHA_01 ,  NFKAPPAB65_01 ,  RYTGCNWTGGNR_UNKNOWN ,  P53_02 ,  CAGGTG_E12_Q6 ,  AREB6_01 ,  CCCNNGGGAR_OLF1_01 ,  TAATAAT_MIR126 ,  WGGAATGY_TEF1_Q6 ,  CP2_02 ,  CREL_01 ,  CTTTGT_LEF1_Q2 ,  ER_Q6_01 ,  NFKB_Q6_01 ,  CAGCTG_AP4_Q5 ,  TGACATY_UNKNOWN ,  NFKB_Q6 ,  NFKB_C ,  CP2_01 ,  ACACTGG_MIR199A_MIR199B

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-199

Cytogenetic Map:

6p21.33

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