QuickView for CD207 (gene)

Gene Symbol:

CD207 Homo sapiens

Full name:

CD207 molecule

Synonyms:

CLEC4K, C-type lectin domain family 4 member K, C-type lectin domain family 4, member K, CD207 antigen, langerin, CD207 molecule, langerin, Langerhans cell specific c-type lectin

Genomic Location:

Chr 2: 70910855-70916461

Description:

The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it ...

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The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway. Mutations in this gene result in Birbeck granules deficiency or loss of sugar binding activity.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Cytogenetic Map:

2p13.3

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