QuickView for CD274 (gene)

Gene Symbol:

CD274 Homo sapiens

Full name:

CD274 molecule

Synonyms:

B7-H, B7H1, PD-L1, PDCD1L1, PDCD1LG1, PDL1, programmed cell death 1 ligand 1, B7 homolog 1, CD274 antigen, PDCD1 ligand 1

Genomic Location:

Chr 9: 5440559-5458477

Description:

This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell act...

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This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

NFAT_Q6 ,  STAT6_02 ,  IPF1_Q4 ,  STAT6_01 ,  CTTTGA_LEF1_Q2 ,  TTCYRGAA_UNKNOWN ,  STAT5A_03 ,  PTF1BETA_Q6 ,  PAX_Q6 ,  AACTTT_UNKNOWN ,  ELF1_Q6

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Cytogenetic Map:

9p24.1

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