QuickView for CD2AP (gene)

Gene Symbol:

CD2AP Homo sapiens

Full name:

CD2 associated protein

Synonyms:

CMS, CD2-associated protein, Cas ligand with multiple Src homology 3 (SH3) domains, adapter protein CMS, cas ligand with multiple SH3 domains

Genomic Location:

Chr 6: 47553484-47702958

Description:

This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, li...

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This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio ,  Bos taurus ,  Gallus gallus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

RTAAACA_FREAC2_01 ,  GTATTAT_MIR3693P ,  CREBP1CJUN_01 ,  CREB_Q4_01 ,  RYTTCCTG_ETS2_B ,  SREBP1_02 ,  TGANNYRGCA_TCF11MAFG_01 ,  STAT6_02 ,  GCANCTGNY_MYOD_Q6 ,  TMTCGCGANR_UNKNOWN ,  CREB_Q4 ,  ACTGTGA_MIR27A_MIR27B ,  GTGCAAT_MIR25_MIR32_MIR92_MIR363_MIR367 ,  TGAYRTCA_ATF3_Q6 ,  ATF_B ,  CREBP1_Q2 ,  TGTATGA_MIR4853P ,  TGCAAAC_MIR452 ,  GTGACGY_E4F1_Q6 ,  GGATTA_PITX2_Q2 ,  ATF_01 ,  CAGGTG_E12_Q6 ,  CREB_02 ,  ATF3_Q6 ,  GGGCGGR_SP1_Q6 ,  TGCTGAY_UNKNOWN ,  GACAATC_MIR219 ,  PITX2_Q2 ,  E4F1_Q6 ,  AREB6_03 ,  TTGCCAA_MIR182 ,  FREAC2_01 ,  ATF1_Q6 ,  CREB_Q2 ,  TGACGTCA_ATF3_Q6 ,  CREB_Q2_01 ,  CREB_01 ,  TAXCREB_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-219 ,  Predicted Gene Targets for miR-221 ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-369-3p ,  Predicted Gene Targets for miR-96 ,  Predicted Gene Targets for miR-137 ,  Predicted Gene Targets for miR-182 ,  Predicted Gene Targets for miR-410 ,  Predicted Gene Targets for miR-452 ,  Predicted Gene Targets for miR-485-3p

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Cytogenetic Map:

6p12.3

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