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QuickView for CD31 (gene)


Gene Symbol:
PECAM1 Homo sapiens Homo sapiens
Full name:
platelet and endothelial cell adhesion molecule 1
Synonyms:
CD31, CD31/EndoCAM, GPIIA', PECA1, PECAM-1, endoCAM, platelet endothelial cell adhesion molecule, CD31 antigen, platelet endothelial cell adhesion molecule-1
Genomic Location:
Chr 17: 59753595-59817743
Description:
The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation.
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Pan troglodytes Danio rerio Canis lupus familiaris Gallus gallus
External Links:
Entrez Gene
Cytogenetic Map:
chr 17
17q23.3





GO Molecular Function

identical protein binding | protein binding | protein homodimerization activity | protein dimerization activity

GO Biological Process

cell morphogenesis | diapedesis | exocytosis | extracellular structure organization | neutrophil extravasation | cell motility | neutrophil activation | intracellular signal transduction | endothelial cell development | regulation of localization | cell-substrate adhesion | positive regulation of peptidyl-tyrosine phosphorylation | establishment of localization | platelet degranulation | cell differentiation | endothelial cell differentiation | glomerulus development | epithelial cell migration | positive regulation of phosphate metabolic process | blood vessel morphogenesis | cellular process | secretion | leukocyte degranulation | regulation of cell motility | localization | epithelium migration | regulation of tyrosine phosphorylation of STAT protein | positive regulation of nitrogen compound metabolic process | tissue development | cell recognition | regulation of cellular process | leukocyte activation | regulation of metabolic process | small GTPase mediated signal transduction | positive regulation of cellular protein metabolic process | epithelium development | cellular component organization | urogenital system development | response to stimulus | vasculature development | neutrophil degranulation | regulation of peptidyl-tyrosine phosphorylation | positive regulation of protein metabolic process | response to stress | positive regulation of JAK-STAT cascade | endothelial cell migration | leukocyte activation involved in immune response | tube morphogenesis | epithelial cell development | secretion by cell | cardiovascular system development | extracellular matrix organization | kidney development | epithelial cell morphogenesis | blood vessel development | leukocyte migration | locomotion | system development | regulation of signal transduction | endothelium development | multicellular organism development | cell migration | glomerulus vasculature development | leukocyte mediated immunity | regulation of phosphorylation | wound healing | kidney epithelium development | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of nitrogen compound metabolic process | regulation of cell migration | positive regulation of STAT cascade | positive regulation of intracellular signal transduction | vesicle-mediated transport | regulation of cellular component movement | endothelial cell-matrix adhesion | regulation of cellular protein metabolic process | angiogenesis | regulated exocytosis | cell morphogenesis involved in differentiation | cell communication | regulation of cellular metabolic process | positive regulation of tyrosine phosphorylation of STAT protein | cell activation involved in immune response | myeloid cell activation involved in immune response | regulation of protein metabolic process | positive regulation of signal transduction | neutrophil activation involved in immune response | regulation of protein phosphorylation | regulation of locomotion | renal system development | nephron development | positive regulation of protein modification process | Rho protein signal transduction | glomerular endothelium development | regulation of JAK-STAT cascade | response to wounding | import into cell | regulation of intracellular signal transduction | anatomical structure development | leukocyte cell-cell adhesion | endocytosis | cell adhesion | immune response | animal organ development | regulation of phosphate metabolic process | cell-cell adhesion | cell activation | anatomical structure formation involved in morphogenesis | regulation of cell communication | signaling | cell-matrix adhesion | cell development | positive regulation of phosphorylation | anatomical structure morphogenesis | developmental process | cellular extravasation | tube development | Ras protein signal transduction | neutrophil mediated immunity | epithelial cell differentiation | cell-cell adhesion via plasma-membrane adhesion molecules | positive regulation of metabolic process | immune system process | ameboidal-type cell migration | endothelial cell morphogenesis | neutrophil migration | circulatory system development | glomerular epithelium development | phagocytosis | positive regulation of signaling | signal transduction | regulation of signaling | homophilic cell adhesion via plasma membrane adhesion molecules | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

secretory granule | supramolecular fiber | integral component of membrane | organelle membrane | cytoplasmic vesicle | platelet alpha granule membrane | cell | intrinsic component of membrane | smooth muscle contractile fiber | external side of plasma membrane | cytoplasm | intracellular organelle | membrane microdomain | platelet alpha granule | secretory granule membrane | contractile fiber | secretory vesicle | endomembrane system | plasma membrane | membrane raft | vesicle | extracellular exosome | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | vesicle membrane | extracellular space | cell periphery | intracellular vesicle | cell surface | intracellular | cell junction | membrane | supramolecular complex | cytoplasmic vesicle membrane