QuickView for CD40 ligand (gene)

Gene Symbol:

CD40LG Homo sapiens

Full name:

CD40 ligand

Synonyms:

CD154, CD40L, HIGM1, IGM, IMD3, T-BAM, TNFSF5, TRAP, gp39, hCD40L, CD40 ligand, CD40 antigen ligand, CD40-L, T-B cell-activating molecule, T-cell antigen Gp39, TNF-related activation protein, tumor necrosis factor (ligand) superfamily member 5

Genomic Location:

Chr X: 135558002-135570215

Description:

The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome.

The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  IRF1_01 ,  OCT1_05 ,  TTANTCA_UNKNOWN ,  RYTTCCTG_ETS2_B ,  CATTGTYY_SOX9_B1 ,  GCANCTGNY_MYOD_Q6 ,  NGFIC_01 ,  TEL2_Q6 ,  VDR_Q6 ,  CTTTGA_LEF1_Q2 ,  OCT1_Q5_01 ,  TTAYRTAA_E4BP4_01 ,  EGR2_01 ,  OCT_C ,  WTGAAAT_UNKNOWN ,  GGGAGGRR_MAZ_Q6 ,  STAT_Q6 ,  OCT1_Q6 ,  GGATTA_PITX2_Q2 ,  STAT5B_01 ,  CAGGTG_E12_Q6 ,  E47_02 ,  CATRRAGC_UNKNOWN ,  CREBP1_01 ,  YKACATTT_UNKNOWN ,  NERF_Q2 ,  MGGAAGTG_GABP_B ,  STAT_01 ,  GFI1_01 ,  HLF_01 ,  TTGTTT_FOXO4_01 ,  YTAAYNGCT_UNKNOWN ,  STAT5A_04 ,  IRF7_01 ,  T3R_Q6 ,  TTCYNRGAA_STAT5B_01 ,  STAT1_01 ,  STAT5A_01 ,  ER_Q6_01 ,  AACTTT_UNKNOWN ,  TGACATY_UNKNOWN ,  EGR3_01

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Cytogenetic Map:

Xq26.3

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