QuickView for CD46 (gene)

Gene Symbol:

CD46 Homo sapiens

Full name:

CD46 molecule

Synonyms:

AHUS2, MCP, MIC10, TLX, TRA2.10, membrane cofactor protein, CD46 antigen, complement regulatory protein, CD46 molecule, complement regulatory protein, antigen identified by monoclonal antibody TRA-2-10, complement membrane cofactor protein, measles virus receptor, membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen), trophoblast leucocyte common antigen, trophoblast leukocyte common antigen, trophoblast-lymphocyte cross-reactive antigen

Genomic Location:

Chr 1: 205992025-206035481

Description:

The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edm...

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The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Cytogenetic Map:

1q32.2

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