QuickView for CD4 (gene)

Gene Symbol:

CD4 Homo sapiens

Full name:

CD4 molecule

Synonyms:

CD4mut, T-cell surface glycoprotein CD4, CD4 antigen (p55), CD4 receptor, T-cell surface antigen T4/Leu-3

Genomic Location:

Chr 12: 6768912-6800237

Description:

This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. T...

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This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

NFMUE1_Q6 ,  SMTTTTGT_UNKNOWN ,  GCGSCMNTTT_UNKNOWN ,  RYTTCCTG_ETS2_B ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  GCCATNTTG_YY1_Q6 ,  YY1_01 ,  GGCNKCCATNK_UNKNOWN ,  TGCCAAR_NF1_Q6 ,  GGCNNMSMYNTTG_UNKNOWN ,  ATGTAGC_MIR221_MIR222

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-221

Cytogenetic Map:

12p13.31

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