QuickView for CD63;jsessionid=3D4D7746C6F752CE93DDD7660CDE2C41 (gene)

Gene Symbol:

CD63 Homo sapiens

Full name:

CD63 molecule

Synonyms:

LAMP-3, ME491, MLA1, OMA81H, TSPAN30, CD63 antigen, CD63 antigen (melanoma 1 antigen), granulophysin, lysosomal-associated membrane protein 3, lysosome-associated membrane glycoprotein 3, melanoma-associated antigen ME491, melanoma-associated antigen MLA1, ocular melanoma-associated antigen, tetraspanin-30, tspan-30

Genomic Location:

Chr 12: 54405497-54409177

Description:

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation,...

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The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Danio rerio ,  Bos taurus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CCAGGTT_MIR490 ,  NF1_Q6 ,  GGGTGGRR_PAX4_03

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-490

Cytogenetic Map:

12q13.2

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