QuickView for CD68 (gene)

Gene Symbol:

CD68 Homo sapiens

Full name:

CD68 molecule

Synonyms:

GP110, LAMP4, SCARD1, macrosialin, CD68 antigen, macrophage antigen CD68, scavenger receptor class D, member 1

Genomic Location:

Chr 17: 7423529-7426153

Description:

This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integra...

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This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  AP1_C ,  TGANTCA_AP1_C ,  TTANTCA_UNKNOWN ,  EFC_Q6 ,  CATTGTYY_SOX9_B1 ,  AAAYWAACM_HFH4_01 ,  PBX1_01 ,  GGGAGGRR_MAZ_Q6 ,  ALPHACP1_01 ,  FREAC3_01 ,  P53_02 ,  YY1_01 ,  FOXJ2_01 ,  YKACATTT_UNKNOWN ,  HFH4_01 ,  POU1F1_Q6 ,  TGTTTGY_HNF3_Q6 ,  TTGTTT_FOXO4_01 ,  SMAD_Q6 ,  TGACATY_UNKNOWN ,  TCF1P_Q6 ,  AP1_Q4_01 ,  HNF6_Q6 ,  MYB_Q3

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Cytogenetic Map:

17p13.1

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