QuickView for CD74 (gene)
- Gene Symbol:
- CD74
Homo sapiens - Full name:
- CD74 molecule
- Synonyms:
- DHLAG, HLADG, II, Ia-GAMMA, HLA class II histocompatibility antigen gamma chain, CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated), CD74 molecule, major histocompatibility complex, class II invariant chain, HLA-DR antigens-associated invariant chain, HLA-DR-gamma, Ia-associated invariant chain, MHC HLA-DR gamma chain, gamma chain of class II antigens, p33
- Genomic Location:
- Chr 5: 149761393-149772525
- Description:
-
The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pat...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Danio rerio , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
5q33.1
GO Molecular Function
MHC protein binding | cytokine binding | peptide binding | amyloid-beta binding | transmembrane signaling receptor activity | enzyme binding | protein-containing complex binding | CD4 receptor binding | signaling receptor binding | amide binding | signaling receptor activity | identical protein binding | MHC class II protein complex binding | macrophage migration inhibitory factor binding | cytokine receptor activity | protein binding involved in protein folding | MHC class II protein binding, via antigen binding groove | protein binding | nitric-oxide synthase binding | MHC class II protein binding
GO Biological Process
positive regulation of immune response | negative regulation of lymphocyte differentiation | negative regulation of leukocyte activation | regulation of leukocyte chemotaxis | regulation of ERK1 and ERK2 cascade | positive regulation of macrophage cytokine production | adaptive immune response | positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | negative regulation of immune system process | regulation of monocyte differentiation | protein heterotetramerization | response to cytokine | regulation of B cell activation | cell motility | antigen processing and presentation | 'de novo' posttranslational protein folding | negative regulation of peptide secretion | regulation of localization | regulation of programmed cell death | positive regulation of peptidyl-tyrosine phosphorylation | establishment of localization | regulation of immune system process | negative regulation of mature B cell apoptotic process | negative regulation of cellular process | negative regulation of leukocyte cell-cell adhesion | positive regulation of developmental process | regulation of MAP kinase activity | positive regulation of lymphocyte activation | cell differentiation | regulation of T cell differentiation | positive regulation of fibroblast proliferation | defense response | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | positive regulation of cellular component movement | intracellular transport | positive regulation of viral life cycle | negative T cell selection | positive regulation of T cell differentiation | positive regulation of cellular biosynthetic process | cellular process | unsaturated fatty acid biosynthetic process | lymphocyte differentiation | regulation of cell motility | localization | chaperone-mediated protein folding | regulation of DNA damage response, signal transduction by p53 class mediator | protein transport | negative regulation of signaling | positive regulation of immune effector process | immune system development | positive regulation of protein kinase activity | macromolecule localization | regulation of response to cytokine stimulus | regulation of chemotaxis | negative regulation of apoptotic process | negative regulation of secretion | positive regulation of catalytic activity | regulation of myeloid cell differentiation | positive regulation of nitrogen compound metabolic process | establishment of localization in cell | regulation of myeloid leukocyte differentiation | regulation of cell differentiation | regulation of lymphocyte apoptotic process | negative regulation of apoptotic signaling pathway | positive regulation of dendritic cell antigen processing and presentation | regulation of immune response | regulation of cellular process | leukocyte activation | regulation of apoptotic process | regulation of metabolic process | positive regulation of neutrophil migration | regulation of type 2 immune response | positive regulation of cellular protein metabolic process | negative thymic T cell selection | icosanoid biosynthetic process | positive regulation of antigen processing and presentation | cellular component organization | cellular lipid metabolic process | regulation of neutrophil chemotaxis | T cell activation | regulation of peptide secretion | response to stimulus | monocarboxylic acid metabolic process | regulation of peptidyl-tyrosine phosphorylation | positive regulation of immune system process | positive regulation of protein metabolic process | negative regulation of cell adhesion | response to stress | intracellular protein transport | negative regulation of lymphocyte activation | positive regulation of lymphocyte proliferation | regulation of cell proliferation | regulation of chemokine (C-X-C motif) ligand 2 production | positive regulation of cell-cell adhesion | positive regulation of B cell proliferation | positive regulation of cell activation | cellular localization | antigen processing and presentation of exogenous peptide antigen via MHC class II | positive regulation of T cell activation | negative regulation of transport | positive regulation of protein serine/threonine kinase activity | positive regulation of RNA biosynthetic process | hemopoiesis | cellular component assembly | negative regulation of hemopoiesis | regulation of peptide transport | regulation of cell adhesion | cellular biosynthetic process | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage | activation of protein kinase activity | negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator | regulation of lymphocyte differentiation | leukocyte migration | regulation of nucleic acid-templated transcription | leukocyte differentiation | regulation of cellular response to stress | locomotion | positive regulation of response to cytokine stimulus | positive regulation of mononuclear cell proliferation | adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | system development | regulation of viral entry into host cell | regulation of signal transduction | antigen processing and presentation of peptide antigen via MHC class II | positive regulation of viral process | multicellular organism development | cell migration | positive regulation of lymphocyte differentiation | regulation of MAPK cascade | antigen processing and presentation of endogenous antigen | protein complex oligomerization | leukocyte mediated immunity | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | lipid metabolic process | regulation of granulocyte chemotaxis | regulation of phosphorylation | regulation of intrinsic apoptotic signaling pathway | regulation of T cell activation | regulation of gene expression | positive regulation of chemotaxis | positive thymic T cell selection | organic substance transport | regulation of signal transduction by p53 class mediator | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of lymphocyte activation | negative regulation of lymphocyte apoptotic process | regulation of nitrogen compound metabolic process | negative regulation of T cell activation | regulation of cell migration | negative regulation of signal transduction by p53 class mediator | small molecule metabolic process | peptide transport | cytokine-mediated signaling pathway | positive regulation of intracellular signal transduction | regulation of cellular component movement | positive regulation of monocyte differentiation | macrophage migration inhibitory factor signaling pathway | positive regulation of cell differentiation | positive regulation of myeloid cell differentiation | positive regulation of cell migration | fatty acid biosynthetic process | cellular response to cytokine stimulus | cell proliferation | biosynthetic process | 'de novo' protein folding | negative regulation of B cell apoptotic process | regulation of cellular protein metabolic process | lipid biosynthetic process | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | protein tetramerization | positive regulation of chemokine production | regulation of apoptotic signaling pathway | regulation of leukocyte migration | regulation of B cell apoptotic process | regulation of macrophage activation | cytokine receptor activity | negative regulation of cell-cell adhesion | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | protein trimerization | positive regulation of leukocyte chemotaxis | negative regulation of cell activation | regulation of cytokine production involved in immune response | regulation of protein metabolic process | protein binding involved in protein folding | positive regulation of signal transduction | positive regulation of cell proliferation | regulation of protein phosphorylation | regulation of cytokine-mediated signaling pathway | regulation of locomotion | regulation of RNA metabolic process | positive regulation of B cell activation | regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | regulation of viral process | negative regulation of T cell differentiation | carboxylic acid metabolic process | lymphocyte activation | positive regulation of molecular function | activation of MAPK activity | T cell differentiation | positive regulation of myeloid leukocyte cytokine production involved in immune response | antigen processing and presentation of exogenous antigen | protein-containing complex assembly | regulation of fibroblast proliferation | positive regulation of type 2 immune response | positive regulation of protein modification process | T cell selection | response to organic substance | T cell differentiation in thymus | regulation of hemopoiesis | regulation of kinase activity | negative regulation of DNA damage response, signal transduction by p53 class mediator | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | anatomical structure development | cell surface receptor signaling pathway | metabolic process | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II | regulation of neutrophil migration | regulation of RNA biosynthetic process | positive regulation of leukocyte activation | negative regulation of programmed cell death | positive regulation of cytokine production involved in immune response | positive regulation of neutrophil chemotaxis | cellular protein localization | positive T cell selection | amide transport | prostaglandin metabolic process | regulation of secretion | regulation of response to DNA damage stimulus | immune response | thymic T cell selection | organic substance metabolic process | negative regulation of intrinsic apoptotic signaling pathway | protein folding | regulation of intrinsic apoptotic signaling pathway in response to DNA damage | animal organ development | regulation of cell activation | positive regulation of leukocyte migration | positive regulation of ERK1 and ERK2 cascade | positive regulation of kinase activity | regulation of phosphate metabolic process | fatty acid metabolic process | establishment of protein localization | positive regulation of cytokine production | cell activation | positive regulation of MAPK cascade | positive regulation of cytokine-mediated signaling pathway | icosanoid metabolic process | regulation of cell communication | negative regulation of signal transduction | regulation of antigen processing and presentation | signaling | positive regulation of I-kappaB kinase/NF-kappaB signaling | regulation of transcription, DNA-templated | positive regulation of chemokine (C-X-C motif) ligand 2 production | positive regulation of viral entry into host cell | protein localization | organic acid metabolic process | negative regulation of leukocyte apoptotic process | positive regulation of phosphorylation | regulation of cytokine production | protein heterooligomerization | cellular macromolecule localization | positive regulation of MAP kinase activity | chaperone cofactor-dependent protein refolding | regulation of developmental process | B cell mediated immunity | regulation of intrinsic apoptotic signaling pathway by p53 class mediator | developmental process | regulation of chemokine production | regulation of transport | positive regulation of transcription, DNA-templated | regulation of B cell proliferation | regulation of cell-cell adhesion | positive regulation of nucleic acid-templated transcription | prostaglandin biosynthetic process | positive regulation of granulocyte chemotaxis | antigen processing and presentation of peptide antigen | positive regulation of metabolic process | immunoglobulin mediated immune response | positive regulation of myeloid leukocyte differentiation | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | cellular response to organic substance | regulation of cell death | positive regulation of cell motility | regulation of viral life cycle | negative regulation of cell death | positive regulation of leukocyte cell-cell adhesion | regulation of I-kappaB kinase/NF-kappaB signaling | negative regulation of cell differentiation | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of gene expression | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
trans-Golgi network membrane | integral component of membrane | intracellular membrane-bounded organelle | ER to Golgi transport vesicle membrane | late endosome | clathrin-coated endocytic vesicle membrane | endocytic vesicle membrane | clathrin-coated vesicle membrane | organelle membrane | clathrin-coated vesicle | cytoplasmic vesicle | Golgi-associated vesicle membrane | cell | integral component of endoplasmic reticulum membrane | multivesicular body | plasma membrane protein complex | COPII-coated ER to Golgi transport vesicle | vacuolar lumen | intrinsic component of membrane | transport vesicle membrane | external side of plasma membrane | cytoplasm | clathrin-coated endocytic vesicle | intracellular organelle | intrinsic component of endoplasmic reticulum membrane | receptor complex | endoplasmic reticulum | NOS2-CD74 complex | Golgi apparatus | nuclear outer membrane-endoplasmic reticulum membrane network | protein-containing complex | integral component of lumenal side of endoplasmic reticulum membrane | endomembrane system | endoplasmic reticulum membrane | plasma membrane | Golgi-associated vesicle | vacuole | vesicle | transport vesicle | extracellular exosome | lytic vacuole | Golgi membrane | endosome | extracellular region | coated vesicle membrane | membrane-bounded organelle | extracellular vesicle | macrophage migration inhibitory factor receptor complex | organelle | vesicle membrane | lysosome | extracellular space | cell periphery | MHC class II protein complex | membrane-enclosed lumen | trans-Golgi network | lysosomal lumen | intracellular vesicle | cell surface | endocytic vesicle | intracellular | lysosomal membrane | membrane | cytoplasmic vesicle membrane | vacuolar membrane | coated vesicle
