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QuickView for CD95L (gene)


Gene Symbol:
FASLG Homo sapiens Homo sapiens
Full name:
Fas ligand
Synonyms:
ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6, TNLG1A, tumor necrosis factor ligand superfamily member 6, CD95 ligand, Fas ligand (TNF superfamily, member 6), apoptosis (APO-1) antigen ligand 1, apoptosis antigen ligand, fas antigen ligand, mutant tumor necrosis factor family member 6, tumor necrosis factor ligand 1A
Genomic Location:
Chr 1: 170894808-170902636
Description:
This gene is a member of the tumor necrosis factor superfamily. The primary function of the encoded transmembrane protein is the induction of apoptosis triggered by binding to FAS. The FAS/FASLG signaling pathway is essential for immune system regulation, including activation-induced cell death (AICD) of T cells and cytotoxic T lymphocyte induced c...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Gallus gallus Canis lupus familiaris Pan troglodytes Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 1
1q24.3


Transcripts Names
NM_000639
NM_001302746
Protein Names
Q9BZP9
P48023
Q53ZZ1



GO Molecular Function

signaling receptor binding | cytokine receptor binding | molecular function regulator | death receptor binding | tumor necrosis factor receptor binding | protein binding | receptor regulator activity | receptor ligand activity | cytokine activity | tumor necrosis factor receptor superfamily binding

GO Biological Process

RNA metabolic process | regulation of cysteine-type endopeptidase activity | response to cytokine | response to lipopolysaccharide | endosomal lumen acidification | calcium ion transmembrane import into cytosol | positive regulation of apoptotic process | cytosolic calcium ion transport | regulation of localization | regulation of programmed cell death | eye development | necroptotic process | establishment of localization | negative regulation of cellular process | negative regulation of RNA biosynthetic process | cell differentiation | cellular chemical homeostasis | regulation of neuron death | necroptotic signaling pathway | cellular process | localization | cellular homeostasis | extrinsic apoptotic signaling pathway | negative regulation of signaling | metal ion transport | anion homeostasis | programmed necrotic cell death | negative regulation of nucleic acid-templated transcription | negative regulation of apoptotic process | endomembrane system organization | regulation of proteolysis | response to growth factor | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | positive regulation of epithelial cell apoptotic process | establishment of localization in cell | negative regulation of cellular metabolic process | negative regulation of apoptotic signaling pathway | regulation of angiogenesis | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | regulation of cytosolic calcium ion concentration | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | cellular component organization | calcium ion homeostasis | pH reduction | inflammatory cell apoptotic process | calcium ion transport into cytosol | regulation of vasculature development | response to stimulus | intracellular pH reduction | positive regulation of protein metabolic process | positive regulation of peptidase activity | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | negative regulation of angiogenesis | positive regulation of cysteine-type endopeptidase activity | programmed cell death | positive regulation of endothelial cell apoptotic process | cellular localization | divalent metal ion transport | cellular monovalent inorganic anion homeostasis | positive regulation of proteolysis | response to molecule of bacterial origin | cellular nitrogen compound metabolic process | extrinsic apoptotic signaling pathway via death domain receptors | negative regulation of metabolic process | cellular biosynthetic process | cell-cell signaling | positive regulation of ERBB signaling pathway | molecular function regulator | metal ion homeostasis | regulation of nucleic acid-templated transcription | apoptotic process | response to external biotic stimulus | system development | nitrogen compound metabolic process | regulation of signal transduction | multicellular organism development | regulation of peptidase activity | calcium ion transmembrane transport | regulation of catalytic activity | ion transmembrane transport | regulation of gene expression | regulation of extrinsic apoptotic signaling pathway | response to lipid | positive regulation of cellular metabolic process | cellular ion homeostasis | animal organ morphogenesis | positive regulation of cytosolic calcium ion concentration | regulation of nitrogen compound metabolic process | regulation of cysteine-type endopeptidase activity involved in apoptotic process | cytokine-mediated signaling pathway | positive regulation of intracellular signal transduction | regulation of transcription by RNA polymerase II | regulation of endothelial cell apoptotic process | positive regulation of hydrolase activity | negative regulation of extrinsic apoptotic signaling pathway | T cell apoptotic process | cellular response to cytokine stimulus | biosynthetic process | negative regulation of sequestering of calcium ion | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | positive regulation of endopeptidase activity | positive regulation of neuron death | regulation of apoptotic signaling pathway | programmed cell death involved in cell development | regulation of epithelial cell apoptotic process | cation homeostasis | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | sensory organ development | response to bacterium | cellular cation homeostasis | cell communication | regulation of cellular metabolic process | eye morphogenesis | regulation of neuron apoptotic process | regulation of intracellular pH | regulation of protein metabolic process | positive regulation of signal transduction | cellular calcium ion homeostasis | homeostatic process | positive regulation of cell proliferation | regulation of RNA metabolic process | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors | apoptotic signaling pathway | positive regulation of molecular function | release of sequestered calcium ion into cytosol | cation transmembrane transport | cellular chloride ion homeostasis | regulation of signaling receptor activity | receptor regulator activity | response to organic substance | regulation of pH | regulation of intracellular signal transduction | positive regulation of neuron apoptotic process | anatomical structure development | chloride ion homeostasis | cell surface receptor signaling pathway | metabolic process | activation of cysteine-type endopeptidase activity involved in apoptotic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | retinal cell programmed cell death | chemical homeostasis | calcium ion transport | positive regulation of cell death | receptor ligand activity | immune response | nucleobase-containing compound metabolic process | cytokine activity | organic substance metabolic process | regulation of sequestering of calcium ion | regulation of epidermal growth factor receptor signaling pathway | cell death | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | gene expression | positive regulation of programmed cell death | ion homeostasis | inorganic cation transmembrane transport | vesicle organization | transcription, DNA-templated | regulation of cellular pH | regulation of cell communication | negative regulation of signal transduction | transmembrane transport | regulation of extrinsic apoptotic signaling pathway via death domain receptors | signaling | positive regulation of I-kappaB kinase/NF-kappaB signaling | regulation of transcription, DNA-templated | cellular monovalent inorganic cation homeostasis | cell development | regulation of ERBB signaling pathway | positive regulation of epidermal growth factor receptor signaling pathway | anatomical structure morphogenesis | release of sequestered calcium ion into cytosol by endoplasmic reticulum | regulation of endopeptidase activity | cation transport | cellular macromolecule biosynthetic process | endosome organization | response to biotic stimulus | regulation of developmental process | developmental process | organelle organization | negative regulation of transcription by RNA polymerase II | necrotic cell death | negative regulation of vasculature development | cellular metal ion homeostasis | heterocycle metabolic process | positive regulation of metabolic process | ion transport | immune system process | cellular metabolic process | cellular response to organic substance | regulation of cell death | negative regulation of cell death | divalent inorganic cation homeostasis | regulation of I-kappaB kinase/NF-kappaB signaling | response to other organism | positive regulation of signaling | signal transduction | regulation of signaling | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

integral component of membrane | intracellular membrane-bounded organelle | cytoplasmic vesicle | cell | vacuolar lumen | intrinsic component of membrane | cytoplasmic vesicle lumen | external side of plasma membrane | cytoplasm | intracellular organelle | membrane microdomain | plasma membrane | membrane raft | vacuole | vesicle | perinuclear region of cytoplasm | extracellular exosome | lytic vacuole | integral component of plasma membrane | extracellular region | membrane-bounded organelle | extracellular vesicle | nucleus | organelle | lysosome | extracellular space | cell periphery | membrane-enclosed lumen | lysosomal lumen | plasma membrane raft | intracellular vesicle | cell surface | intracellular | caveola | membrane | vesicle lumen | intrinsic component of plasma membrane