QuickView for CDC14B (gene)

Gene Symbol:

CDC14B Homo sapiens

Full name:

cell division cycle 14B

Synonyms:

CDC14B3, Cdc14B1, Cdc14B2, hCDC14B, dual specificity protein phosphatase CDC14B, CDC14 cell division cycle 14 homolog B

Genomic Location:

Chr 9: 98302216-98421933

Description:

The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown ...

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The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CGTSACG_PAX3_B ,  GATTGGY_NFY_Q6_01 ,  CACTGTG_MIR128A_MIR128B ,  CMYB_01 ,  CREB_Q4_01 ,  ATF4_Q2 ,  CREB_Q4 ,  WHN_B ,  STAT_Q6 ,  GTGACGY_E4F1_Q6 ,  CCTGTGA_MIR513 ,  NFY_Q6_01 ,  CREB_02 ,  GTGCCTT_MIR506 ,  TTGTTT_FOXO4_01 ,  CREB_Q2 ,  AACTTT_UNKNOWN

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miRNA binding sites
(Source: miRecords):

hsa-miR-15a/hsa-miR-16 Targeted Genes ,  hsa-miR-124 Targeted Genes

Cytogenetic Map:

9q22.32-q22.33

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