QuickView for CDH13 (gene)

Gene Symbol:

CDH13 Homo sapiens

Full name:

cadherin 13

Synonyms:

CDHH, P105, cadherin-13, H-cadherin (heart), T-cad, T-cadherin, cadherin 13, H-cadherin (heart), heart cadherin

Genomic Location:

Chr 16: 81218079-82387702

Description:

This gene encodes a member of the cadherin superfamily. The encoded protein is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. The protein lacks the cytoplasmic domain characteristic of other cadherins, and so is not thought to be a cell-cell adhesion glycoprotein. This protein a...

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This gene encodes a member of the cadherin superfamily. The encoded protein is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. The protein lacks the cytoplasmic domain characteristic of other cadherins, and so is not thought to be a cell-cell adhesion glycoprotein. This protein acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. The gene is hypermethylated in many types of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

OCT1_B ,  OCT1_04 ,  AREB6_02 ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  CAGGTCC_MIR492 ,  GCANCTGNY_MYOD_Q6 ,  AAANWWTGC_UNKNOWN ,  LYF1_01 ,  MEIS1BHOXA9_01 ,  ATGTACA_MIR493 ,  TAAYNRNNTCC_UNKNOWN ,  CTTTGA_LEF1_Q2 ,  MAF_Q6 ,  TGACCTY_ERR1_Q2 ,  YAATNRNNNYNATT_UNKNOWN ,  CDPCR3HD_01 ,  GGGYGTGNY_UNKNOWN ,  CEBP_01 ,  CAGGTG_E12_Q6 ,  AP4_01 ,  GTTTGTT_MIR495 ,  AREB6_01 ,  PTF1BETA_Q6 ,  GFI1_01 ,  MYB_Q6 ,  POU3F2_02 ,  YTAAYNGCT_UNKNOWN ,  AFP1_Q6 ,  SMAD4_Q6 ,  CTGCAGY_UNKNOWN ,  TGATTTRY_GFI1_01 ,  CAGCTG_AP4_Q5 ,  AACTTT_UNKNOWN

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-370 ,  Predicted Gene Targets for miR-493-5p ,  Predicted Gene Targets for miR-495 ,  Predicted Gene Targets for miR-543

Cytogenetic Map:

16q23.3

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