QuickView for CDK2 (gene)
- Gene Symbol:
- CDK2
Homo sapiens - Full name:
- cyclin dependent kinase 2
- Synonyms:
- CDKN2, p33(CDK2), cyclin-dependent kinase 2, cdc2-related protein kinase, cell division protein kinase 2, p33 protein kinase
- Genomic Location:
- Chr 12: 54646826-54652835
- Description:
-
This gene encodes a member of a family of serine/threonine protein kinases that participate in cell cycle regulation. The encoded protein is the catalytic subunit of the cyclin-dependent protein kinase complex, which regulates progression through the cell cycle. Activity of this protein is especially critical during the G1 to S phase transition. Th...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Saccharomyces cerevisiae , Macaca mulatta , Schizosaccharomyces pombe , Danio rerio , Pan troglodytes , Bos taurus , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
OCT1_05 , OCT1_B , HNF1_01 , TCANNTGAY_SREBP1_01 , OCT1_01 , HEN1_01 , YATGNWAAT_OCT_C , OCT_Q6 , CATTGTYY_SOX9_B1 , MYB_Q5_01
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
12q13.2
GO Molecular Function
cyclin binding | cation binding | ribonucleotide binding | nucleotide binding | cyclin-dependent protein kinase activity | carbohydrate derivative binding | protein serine/threonine kinase activity | catalytic activity | protein domain specific binding | ATP binding | anion binding | adenyl nucleotide binding | purine nucleotide binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | histone kinase activity | cyclin-dependent protein serine/threonine kinase activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | metal ion binding | heterocyclic compound binding | small molecule binding
GO Biological Process
regulation of cell cycle process | positive regulation of macromolecule biosynthetic process | intracellular signal transduction | proteolysis | regulation of cell cycle G1/S phase transition | peptidyl-amino acid modification | establishment of localization | negative regulation of cellular process | negative regulation of RNA biosynthetic process | histone modification | microtubule cytoskeleton organization | response to drug | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | regulation of G1/S transition of mitotic cell cycle | regulation of DNA replication | microtubule-based process | positive regulation of cellular biosynthetic process | cellular process | organic substance catabolic process | localization | proteolysis involved in cellular protein catabolic process | chromatin organization | mitotic DNA integrity checkpoint | metal ion transport | cellular response to nitric oxide | negative regulation of G1/S transition of mitotic cell cycle | negative regulation of nucleic acid-templated transcription | microtubule organizing center organization | regulation of cell cycle | positive regulation of nitrogen compound metabolic process | response to inorganic substance | negative regulation of cellular metabolic process | regulation of cellular process | regulation of metabolic process | catabolic process | small GTPase mediated signal transduction | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | signal transduction involved in mitotic DNA damage checkpoint | regulation of G2/M transition of mitotic cell cycle | cellular component organization | response to stimulus | cyclin-dependent protein kinase activity | regulation of mitotic cell cycle phase transition | response to stress | regulation of cell proliferation | anaphase-promoting complex-dependent catabolic process | regulation of cell cycle phase transition | protein serine/threonine kinase activity | reproduction | cellular response to inorganic substance | cellular protein catabolic process | regulation of gene silencing | cellular nitrogen compound metabolic process | proteasomal protein catabolic process | cell cycle G1/S phase transition | positive regulation of DNA-dependent DNA replication initiation | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | cellular component assembly | protein modification process | cellular biosynthetic process | macromolecule modification | DNA repair | regulation of nucleic acid-templated transcription | response to nitrogen compound | organelle assembly | regulation of cell cycle G2/M phase transition | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | negative regulation of mitotic cell cycle phase transition | DNA damage response, signal transduction by p53 class mediator | mitotic DNA damage checkpoint | centriole replication | positive regulation of DNA replication | phosphorus metabolic process | cellular response to DNA damage stimulus | cellular response to oxidative stress | positive regulation of cell cycle | signal transduction in response to DNA damage | regulation of gene expression | cellular response to stress | cell cycle | protein catabolic process | regulation of signal transduction by p53 class mediator | regulation of cell cycle arrest | positive regulation of cellular metabolic process | monovalent inorganic cation transport | regulation of nitrogen compound metabolic process | regulation of DNA-dependent DNA replication initiation | regulation of transcription by RNA polymerase II | response to oxidative stress | potassium ion transport | biosynthetic process | cell division | G2/M transition of mitotic cell cycle | phosphorylation | signal transduction involved in cell cycle checkpoint | regulation of DNA-dependent DNA replication | mitotic cell cycle phase transition | protein phosphorylation | phosphate-containing compound metabolic process | cellular response to drug | mitotic G1 DNA damage checkpoint | cell communication | regulation of cellular metabolic process | cell cycle G2/M phase transition | G1/S transition of mitotic cell cycle | positive regulation of cell proliferation | regulation of RNA metabolic process | histone phosphorylation | proteasome-mediated ubiquitin-dependent protein catabolic process | regulation of mitotic cell cycle | positive regulation of cell cycle arrest | protein metabolic process | centrosome duplication | G1 DNA damage checkpoint | centrosome cycle | histone kinase activity | cellular response to reactive nitrogen species | DNA metabolic process | cyclin-dependent protein serine/threonine kinase activity | centriole assembly | regulation of intracellular signal transduction | cellular macromolecule catabolic process | mitotic cell cycle | metabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | negative regulation of mitotic cell cycle | nucleobase-containing compound metabolic process | protein kinase activity | cellular response to reactive oxygen species | positive regulation of DNA-dependent DNA replication | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | response to reactive oxygen species | signal transduction involved in mitotic cell cycle checkpoint | cytoskeleton organization | ubiquitin-dependent protein catabolic process | negative regulation of cell cycle | organonitrogen compound catabolic process | meiotic cell cycle | regulation of cell communication | negative regulation of cell cycle G1/S phase transition | signaling | covalent chromatin modification | regulation of transcription, DNA-templated | cellular protein metabolic process | cation transport | cellular macromolecule biosynthetic process | signal transduction involved in DNA damage checkpoint | positive regulation of DNA metabolic process | kinase activity | organelle organization | positive regulation of cell cycle process | peptidyl-serine phosphorylation | cellular protein modification process | mitotic G1/S transition checkpoint | negative regulation of transcription by RNA polymerase II | positive regulation of transcription, DNA-templated | Ras protein signal transduction | positive regulation of nucleic acid-templated transcription | cell cycle phase transition | heterocycle metabolic process | signal transduction involved in mitotic G1 DNA damage checkpoint | positive regulation of metabolic process | chromosome organization | ion transport | mitotic cell cycle checkpoint | cellular metabolic process | negative regulation of cell cycle process | response to nitric oxide | modification-dependent protein catabolic process | DNA damage checkpoint | cell cycle checkpoint | signal transduction by p53 class mediator | DNA replication | signal transduction | regulation of signaling | positive regulation of gene expression | macromolecule metabolic process
GO Cellular Component
chromosome | intracellular membrane-bounded organelle | catalytic complex | microtubule organizing center | cytoplasmic vesicle | cyclin A1-CDK2 complex | protein kinase complex | cell | nuclear lumen | sex chromosome | transcription factor complex | cytoplasm | intracellular organelle | Cajal body | nuclear body | centrosome | Y chromosome | protein-containing complex | cyclin E1-CDK2 complex | endomembrane system | nucleoplasm | vesicle | transferase complex | microtubule cytoskeleton | cyclin A2-CDK2 complex | chromosome, telomeric region | cyclin E2-CDK2 complex | endosome | serine/threonine protein kinase complex | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | X chromosome | cyclin-dependent protein kinase holoenzyme complex | cytosol | intracellular vesicle | cytoskeleton | intracellular | condensed chromosome
