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QuickView for CDK5 (gene)


Gene Symbol:
CDK5 Homo sapiens Homo sapiens
Full name:
cyclin dependent kinase 5
Synonyms:
LIS7, PSSALRE, cyclin-dependent-like kinase 5, TPKII catalytic subunit, cell division protein kinase 5, protein kinase CDK5 splicing, serine/threonine-protein kinase PSSALRE, tau protein kinase II catalytic subunit
Genomic Location:
Chr 7: 150381832-150385929
Description:
This gene encodes a proline-directed serine/threonine kinase that is a member of the cyclin-dependent kinase family of proteins. Unlike other members of the family, the protein encoded by this gene does not directly control cell cycle regulation. Instead the protein, which is predominantly expressed at high levels in mammalian postmitotic central n...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Saccharomyces cerevisiae Macaca mulatta Gallus gallus Schizosaccharomyces pombe Bos taurus Pan troglodytes Canis lupus familiaris Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 7
7q36.1


Transcripts Names
NM_004935
NM_001164410



GO Molecular Function

tau-protein kinase activity | ephrin receptor binding | kinase binding | protein kinase binding | enzyme binding | ribonucleotide binding | nucleotide binding | acetylcholine receptor regulator activity | cyclin-dependent protein kinase activity | signaling receptor binding | carbohydrate derivative binding | protein serine/threonine kinase activity | molecular function regulator | catalytic activity | ErbB-3 class receptor binding | ATP binding | cytoskeletal protein binding | anion binding | adenyl nucleotide binding | p53 binding | purine nucleotide binding | acetylcholine receptor activator activity | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | receptor regulator activity | cyclin-dependent protein serine/threonine kinase activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | microtubule binding | Hsp90 protein binding | purine ribonucleotide binding | tubulin binding | adenyl ribonucleotide binding | drug binding | kinase activity | heat shock protein binding | ErbB-2 class receptor binding | heterocyclic compound binding | receptor activator activity | small molecule binding

GO Biological Process

synaptic vesicle exocytosis | maintenance of protein location in nucleus | tau-protein kinase activity | brain development | response to radiation | cell morphogenesis | negative regulation of intracellular transport | serine phosphorylation of STAT protein | regulation of cell cycle process | regulation of intracellular protein transport | actin filament-based process | exocytosis | positive regulation of cellular component organization | cell motility | regulation of cell morphogenesis | regulation of neurogenesis | neuron projection morphogenesis | neurotransmitter secretion | regulation of cellular localization | muscle tissue development | positive regulation of apoptotic process | regulation of cell development | regulation of localization | cell-substrate adhesion | regulation of programmed cell death | peptidyl-amino acid modification | Schwann cell differentiation | hippocampus development | actin cytoskeleton organization | establishment of localization | regulation of autophagy | neuron death | negative regulation of neuron death | neuron migration | negative regulation of cellular process | negative regulation of RNA biosynthetic process | microtubule cytoskeleton organization | regulation of protein localization to membrane | cell differentiation | excitatory postsynaptic potential | positive regulation of signaling receptor activity | nervous system development | response to drug | positive regulation of glial cell apoptotic process | cerebellum morphogenesis | cell part morphogenesis | neurogenesis | positive regulation of phosphate metabolic process | regulation of organelle organization | generation of neurons | intracellular transport | microtubule-based process | negative regulation of proteolysis | regulation of neuron death | neuron projection extension | calcium ion import | cellular process | secretion | negative regulation of axonogenesis | peripheral nervous system development | organic substance catabolic process | establishment of organelle localization | regulation of cell motility | regulation of dendritic spine morphogenesis | localization | cell projection morphogenesis | protein transport | forebrain cell migration | metal ion transport | developmental growth | visual learning | chemical synaptic transmission | neuron development | negative regulation of developmental growth | central nervous system neuron differentiation | synapse assembly | negative regulation of nucleic acid-templated transcription | learning | positive regulation of protein kinase activity | macromolecule localization | axon guidance | regulation of proteolysis | regulation of cell cycle | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | regulation of neuron projection development | regulation of protein export from nucleus | establishment of localization in cell | negative regulation of establishment of protein localization | negative regulation of cellular metabolic process | tissue development | regulation of binding | regulation of cell differentiation | muscle structure development | skeletal muscle organ development | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | gliogenesis | catabolic process | organelle localization | cortical actin cytoskeleton organization | positive regulation of cellular protein metabolic process | cellular response to organonitrogen compound | cellular component organization | negative regulation of cell morphogenesis involved in differentiation | positive regulation of protein binding | head development | acetylcholine receptor regulator activity | associative learning | response to stimulus | peptidyl-threonine phosphorylation | negative regulation of protein transport | cyclin-dependent protein kinase activity | cell morphogenesis involved in neuron differentiation | regulation of cellular protein localization | metencephalon development | cerebral cortex radial glia guided migration | positive regulation of protein metabolic process | response to cocaine | negative regulation of intracellular protein transport | response to stress | neuron projection guidance | intracellular protein transport | positive regulation of cellular protein localization | skeletal muscle tissue development | negative regulation of neuron projection development | regulation of protein ubiquitination | response to peptide | protein localization to nucleus | telencephalon cell migration | receptor clustering | protein serine/threonine kinase activity | programmed cell death | regulation of neurotransmitter receptor activity | cellular localization | divalent metal ion transport | secretion by cell | rhythmic process | maintenance of protein localization in organelle | regulation of macroautophagy | negative regulation of transport | regulation of protein transport | negative regulation of metabolic process | regulation of cellular component size | cellular component assembly | regulation of axon extension | protein modification process | regulation of actin cytoskeleton reorganization | regulation of synapse structure or activity | regulation of peptide transport | modulation of chemical synaptic transmission | mitochondrion organization | macromolecule modification | cell-cell signaling | synaptic transmission, dopaminergic | regulation of intracellular transport | molecular function regulator | cell surface receptor signaling pathway involved in cell-cell signaling | regulation of nucleic acid-templated transcription | regulation of membrane potential | positive regulation of exocytosis | regulation of neurotransmitter levels | locomotion | response to nitrogen compound | central nervous system neuron development | apoptotic process | synaptic vesicle cycle | response to light stimulus | system development | nitrogen compound metabolic process | regulation of signal transduction | positive regulation of organelle organization | negative regulation of growth | regulation of actin cytoskeleton organization | multicellular organism development | cell migration | regulation of synaptic transmission, glutamatergic | phosphorus metabolic process | learning or memory | regulation of axonogenesis | regulation of catalytic activity | cerebellum development | regulation of phosphorylation | negative regulation of cellular protein localization | localization within membrane | synaptic vesicle recycling | telencephalon development | regulation of neuron differentiation | regulation of gene expression | regulation of postsynaptic membrane potential | protein localization to membrane | axon development | positive regulation of secretion | organic substance transport | nervous system process | cellular response to peptide | cell cycle | synaptic signaling | positive regulation of intracellular protein transport | regulation of cell cycle arrest | positive regulation of cellular metabolic process | positive regulation of actin cytoskeleton reorganization | positive regulation of protein phosphorylation | response to ammonium ion | regulation of synapse organization | protein autophosphorylation | regulation of nitrogen compound metabolic process | regulation of cell migration | glial cell migration | neuron apoptotic process | peptide transport | vesicle-mediated transport | regulation of cellular component movement | synapse organization | axonogenesis | protein localization to organelle | behavioral response to cocaine | synaptic transmission, glutamatergic | cognition | acetylcholine receptor activator activity | establishment of vesicle localization | cell proliferation | cell division | sensory perception of pain | regulation of cellular protein metabolic process | glial cell differentiation | hindbrain development | phosphorylation | regulated exocytosis | positive regulation of neuron death | negative regulation of protein export from nucleus | cerebral cortex cell migration | response to xenobiotic stimulus | protein phosphorylation | cell morphogenesis involved in differentiation | phosphate-containing compound metabolic process | positive regulation of regulated secretory pathway | maintenance of protein location | protein localization to synapse | striated muscle tissue development | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | positive regulation of protein localization to membrane | regulation of neuron apoptotic process | synaptic vesicle endocytosis | cellular response to amyloid-beta | cerebellar cortex morphogenesis | positive regulation of cytoskeleton organization | regulation of protein metabolic process | limbic system development | positive regulation of establishment of protein localization | regulation of protein phosphorylation | regulation of locomotion | regulation of RNA metabolic process | negative regulation of protein ubiquitination | positive regulation of transport | cerebral cortex development | negative regulation of cell growth | positive regulation of molecular function | regulation of nucleocytoplasmic transport | neuron differentiation | regulation of signaling receptor activity | receptor regulator activity | regulation of cell morphogenesis involved in differentiation | protein metabolic process | regulation of establishment of protein localization | positive regulation of protein modification process | regulation of growth | response to organic substance | receptor catabolic process | negative regulation of cell projection organization | visual behavior | regulation of JAK-STAT cascade | regulation of kinase activity | response to wounding | import into cell | cyclin-dependent protein serine/threonine kinase activity | axon extension | regulation of intracellular signal transduction | regulation of exocytosis | positive regulation of neuron apoptotic process | anatomical structure development | Schwann cell development | developmental growth involved in morphogenesis | regulation of dendrite morphogenesis | negative regulation of synaptic plasticity | cell surface receptor signaling pathway | cell projection organization | metabolic process | positive regulation of calcium ion-dependent exocytosis | regulation of protein localization to plasma membrane | regulation of protein targeting | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | cellular protein localization | oligodendrocyte differentiation | cerebellar cortex development | amide transport | regulation of vesicle-mediated transport | negative regulation of axon extension | hindbrain morphogenesis | calcium ion regulated exocytosis | calcium ion transport | endocytosis | regulation of secretion | behavior | positive regulation of cell death | cell adhesion | protein kinase activity | neuron projection development | organic substance metabolic process | nuclear transport | cell death | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | cerebral cortex radially oriented cell migration | forebrain development | negative regulation of neuron differentiation | pallium development | negative regulation of cellular protein metabolic process | positive regulation of programmed cell death | positive regulation of kinase activity | maintenance of protein location in cell | regulation of phosphate metabolic process | cytoskeleton organization | response to alkaloid | positive regulation of binding | establishment of protein localization | regulation of regulated secretory pathway | positive regulation of intracellular transport | regulation of postsynapse organization | positive regulation of protein transport | dendrite morphogenesis | anatomical structure formation involved in morphogenesis | negative regulation of cell cycle | adult behavior | negative regulation of protein metabolic process | regulation of dendrite development | sensory perception | cerebellar cortex formation | regulation of cell communication | regulation of dendritic spine development | signaling | response to amyloid-beta | regulation of transcription, DNA-templated | cell-matrix adhesion | regulation of protein binding | glial cell development | response to organic cyclic compound | cell development | regulation of developmental growth | synaptic vesicle localization | protein localization | positive regulation of phosphorylation | cellular protein metabolic process | regulation of cell size | anatomical structure morphogenesis | cation transport | cellular macromolecule localization | nucleocytoplasmic transport | regulation of synaptic vesicle recycling | dendrite development | regulation of nervous system development | regulation of developmental process | kinase activity | developmental process | layer formation in cerebral cortex | organelle organization | regulation of cell growth | peptidyl-serine phosphorylation | cellular protein modification process | positive regulation of protein targeting to membrane | cortical cytoskeleton organization | regulation of transport | developmental cell growth | neurotransmitter transport | receptor metabolic process | signal release | response to organonitrogen compound | regulation of calcium ion-dependent exocytosis | central nervous system development | response to anesthetic | positive regulation of metabolic process | regulation of actin filament-based process | regulation of synaptic plasticity | vesicle localization | ion transport | regulation of cell projection organization | corpus callosum development | cellular metabolic process | synaptic vesicle transport | cellular response to organic substance | regulation of protein localization | regulation of cell death | negative regulation of cell death | negative regulation of cell development | chemotaxis | receptor activator activity | motor neuron axon guidance | negative regulation of cell differentiation | regulation of cellular component organization | muscle organ development | regulation of cytoskeleton organization | signal transduction | regulation of signaling | macromolecule metabolic process | negative regulation of neurogenesis | maintenance of location in cell | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

supramolecular fiber | dendrite | intracellular membrane-bounded organelle | synapse | catalytic complex | neuron projection | somatodendritic compartment | neuromuscular junction | cell body | protein kinase complex | actin-based cell projection | cell | nuclear lumen | neuronal cell body | distal axon | synaptic membrane | lamellipodium | microtubule | cytoplasm | intracellular organelle | dendritic tree | presynapse | protein-containing complex | cell projection | postsynaptic membrane | postsynapse | nucleoplasm | plasma membrane | perikaryon | cell leading edge | transferase complex | postsynaptic density | microtubule cytoskeleton | asymmetric synapse | site of polarized growth | serine/threonine protein kinase complex | membrane-bounded organelle | filopodium | nucleus | organelle | postsynaptic specialization | cell periphery | axon | membrane-enclosed lumen | growth cone | cytosol | cytoskeleton | intracellular | cell junction | membrane | supramolecular complex | protein kinase 5 complex