QuickView for CDK7 (gene)
- Gene Symbol:
- CDK7
Homo sapiens - Full name:
- cyclin dependent kinase 7
- Synonyms:
- CAK, CAK1, CDKN7, HCAK, MO15, STK1, p39MO15, cyclin-dependent kinase 7, 39 KDa protein kinase, CDK-activating kinase 1, TFIIH basal transcription factor complex kinase subunit, cell division protein kinase 7, cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase), homolog of Xenopus MO15 Cdk-activating kinase, kinase subunit of CAK, serine/threonine kinase stk1, serine/threonine protein kinase 1, serine/threonine protein kinase MO15
- Genomic Location:
- Chr 5: 68566471-68609006
- Description:
-
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H an...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Saccharomyces cerevisiae , Macaca mulatta , Schizosaccharomyces pombe , Danio rerio , Pan troglodytes , Bos taurus , Canis lupus familiaris , Gallus gallus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
5q13.2
GO Molecular Function
hormone receptor binding | ribonucleotide binding | nucleotide binding | cyclin-dependent protein kinase activity | signaling receptor binding | hydrolase activity | carbohydrate derivative binding | protein serine/threonine kinase activity | ATPase activity | pyrophosphatase activity | RNA polymerase II CTD heptapeptide repeat kinase activity | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | nucleoside-triphosphatase activity | androgen receptor binding | ATPase activity, coupled | purine nucleotide binding | nuclear hormone receptor binding | ion binding | organic cyclic compound binding | transcription coactivator activity | purine ribonucleoside triphosphate binding | protein binding | transcription factor binding | cyclin-dependent protein serine/threonine kinase activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | hydrolase activity, acting on acid anhydrides | protein kinase activity | transferase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | DNA-dependent ATPase activity | steroid hormone receptor binding | drug binding | kinase activity | transcription coregulator activity | heterocyclic compound binding | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | protein C-terminus binding | small molecule binding
GO Biological Process
RNA metabolic process | transcription by RNA polymerase II | DNA-templated transcription, initiation | positive regulation of macromolecule biosynthetic process | snRNA metabolic process | RNA processing | protein stabilization | response to hormone | transcription initiation from RNA polymerase I promoter | negative regulation of cellular process | androgen receptor signaling pathway | hormone-mediated signaling pathway | positive regulation of cellular biosynthetic process | cellular process | 7-methylguanosine mRNA capping | regulation of cell cycle | positive regulation of nitrogen compound metabolic process | snRNA transcription | regulation of cellular process | cellular response to lipid | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | cellular component organization | response to stimulus | cyclin-dependent protein kinase activity | response to stress | transcription by RNA polymerase I | cellular nitrogen compound biosynthetic process | snRNA transcription by RNA polymerase II | protein serine/threonine kinase activity | protein-DNA complex assembly | cellular nitrogen compound metabolic process | cellular response to organic cyclic compound | positive regulation of RNA biosynthetic process | cellular component assembly | protein modification process | steroid hormone mediated signaling pathway | mRNA metabolic process | RNA polymerase II CTD heptapeptide repeat kinase activity | cellular biosynthetic process | macromolecule modification | DNA repair | regulation of nucleic acid-templated transcription | cellular response to hormone stimulus | regulation of cyclin-dependent protein serine/threonine kinase activity | nitrogen compound metabolic process | regulation of protein stability | phosphorus metabolic process | cellular response to DNA damage stimulus | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | ncRNA transcription | regulation of gene expression | cellular response to stress | response to lipid | cell cycle | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | regulation of transcription by RNA polymerase II | cell proliferation | biosynthetic process | cell division | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | phosphorylation | cellular protein-containing complex assembly | transcription elongation from RNA polymerase II promoter | protein phosphorylation | phosphate-containing compound metabolic process | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of protein metabolic process | regulation of protein phosphorylation | transcription coactivator activity | regulation of RNA metabolic process | DNA-templated transcription, termination | protein-containing complex assembly | protein metabolic process | response to organic substance | cell cycle arrest | regulation of kinase activity | DNA metabolic process | cyclin-dependent protein serine/threonine kinase activity | metabolic process | nucleotide-excision repair | regulation of RNA biosynthetic process | nucleobase-containing compound metabolic process | protein kinase activity | organic substance metabolic process | gene expression | regulation of phosphate metabolic process | cellular response to steroid hormone stimulus | transcription initiation from RNA polymerase II promoter | transcription, DNA-templated | intracellular receptor signaling pathway | negative regulation of cell cycle | transcription-coupled nucleotide-excision repair | signaling | regulation of transcription, DNA-templated | response to organic cyclic compound | cellular protein metabolic process | cellular macromolecule biosynthetic process | kinase activity | intracellular steroid hormone receptor signaling pathway | cellular protein modification process | positive regulation of transcription, DNA-templated | 7-methylguanosine RNA capping | ncRNA metabolic process | positive regulation of nucleic acid-templated transcription | transcription coregulator activity | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | positive regulation of metabolic process | cellular metabolic process | mRNA processing | cellular response to organic substance | response to steroid hormone | termination of RNA polymerase I transcription | signal transduction | nucleotide-excision repair, preincision complex assembly | positive regulation of gene expression | macromolecule metabolic process | DNA-templated transcription, elongation | regulation of phosphorus metabolic process
GO Cellular Component
nuclear transcription factor complex | intracellular membrane-bounded organelle | catalytic complex | RNA polymerase II transcription factor complex | protein kinase complex | cell | nuclear lumen | transcription factor complex | cytoplasm | intracellular organelle | carboxy-terminal domain protein kinase complex | protein-containing complex | nucleoplasm | nuclear cyclin-dependent protein kinase holoenzyme complex | transferase complex | perinuclear region of cytoplasm | serine/threonine protein kinase complex | TFIIK complex | membrane-bounded organelle | holo TFIIH complex | nucleus | organelle | nuclear DNA-directed RNA polymerase complex | RNA polymerase complex | membrane-enclosed lumen | cyclin-dependent protein kinase holoenzyme complex | intracellular | cyclin-dependent protein kinase activating kinase holoenzyme complex | RNA polymerase II, holoenzyme
