QuickView for CDK8 (gene)
- Gene Symbol:
- CDK8
Homo sapiens - Full name:
- cyclin dependent kinase 8
- Synonyms:
- K35, cyclin-dependent kinase 8, CDK8 protein kinase, cell division protein kinase 8, mediator complex subunit CDK8, mediator of RNA polymerase II transcription subunit CDK8, protein kinase K35
- Genomic Location:
- Chr 13: 25726756-25876569
- Description:
-
This gene encodes a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit, cyclin C, are components of the Mediator transcriptional regulatory complex, involved in both transcriptional activation and repression by phosphor...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
13q12.13
GO Molecular Function
ribonucleotide binding | nucleotide binding | cyclin-dependent protein kinase activity | carbohydrate derivative binding | protein serine/threonine kinase activity | RNA polymerase II CTD heptapeptide repeat kinase activity | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | purine nucleotide binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | cyclin-dependent protein serine/threonine kinase activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | heterocyclic compound binding | small molecule binding
GO Biological Process
RNA metabolic process | transcription by RNA polymerase II | DNA-templated transcription, initiation | positive regulation of macromolecule biosynthetic process | positive regulation of cellular biosynthetic process | cellular process | regulation of cell cycle | positive regulation of nitrogen compound metabolic process | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | cyclin-dependent protein kinase activity | cellular nitrogen compound biosynthetic process | protein serine/threonine kinase activity | cellular nitrogen compound metabolic process | positive regulation of RNA biosynthetic process | protein modification process | RNA polymerase II CTD heptapeptide repeat kinase activity | cellular biosynthetic process | macromolecule modification | regulation of nucleic acid-templated transcription | nitrogen compound metabolic process | phosphorus metabolic process | regulation of gene expression | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | regulation of transcription by RNA polymerase II | biosynthetic process | aromatic compound biosynthetic process | phosphorylation | protein phosphorylation | phosphate-containing compound metabolic process | regulation of cellular metabolic process | regulation of RNA metabolic process | protein metabolic process | cyclin-dependent protein serine/threonine kinase activity | metabolic process | regulation of RNA biosynthetic process | nucleobase-containing compound metabolic process | protein kinase activity | organic substance metabolic process | gene expression | transcription initiation from RNA polymerase II promoter | transcription, DNA-templated | regulation of transcription, DNA-templated | cellular protein metabolic process | cellular macromolecule biosynthetic process | kinase activity | cellular protein modification process | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | positive regulation of metabolic process | cellular metabolic process | positive regulation of gene expression | macromolecule metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | cell | nuclear lumen | nucleolus | intracellular organelle | protein-containing complex | nucleoplasm | mediator complex | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | intracellular
