QuickView for CDKN1 (gene)

Gene Symbol:

CDKN1A Homo sapiens

Full name:

cyclin dependent kinase inhibitor 1A

Synonyms:

CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1, cyclin-dependent kinase inhibitor 1, CDK-interacting protein 1, CDK-interaction protein 1, DNA synthesis inhibitor, cyclin-dependent kinase inhibitor 1A (p21, Cip1), melanoma differentiation associated protein 6, wild-type p53-activated fragment 1

Genomic Location:

Chr 6: 36754465-36763087

Description:

This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, thro...

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This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack this gene have the ability to regenerate damaged or missing tissue. Multiple alternatively spliced variants have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CGTSACG_PAX3_B ,  TGGAAA_NFAT_Q4_01 ,  FOXO1_02 ,  RTAAACA_FREAC2_01 ,  HNF3ALPHA_Q6 ,  PR_02 ,  TGANTCA_AP1_C ,  RYTTCCTG_ETS2_B ,  FOX_Q2 ,  P53_DECAMER_Q2 ,  ROAZ_01 ,  YTATTTTNR_MEF2_02 ,  SMAD3_Q6 ,  CATTGTYY_SOX9_B1 ,  E2F_Q6_01 ,  WGTTNNNNNAAA_UNKNOWN ,  AP1_Q6 ,  TGACCTY_ERR1_Q2 ,  TAAWWATAG_RSRFC4_Q2 ,  GGGAGGRR_MAZ_Q6 ,  NFE2_01 ,  CACCCBINDINGFACTOR_Q6 ,  GTGACGY_E4F1_Q6 ,  FREAC3_01 ,  P53_02 ,  AP1_01 ,  TTCYRGAA_UNKNOWN ,  GR_Q6 ,  AR_01 ,  HNF3_Q6 ,  BACH2_01 ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  ATF3_Q6 ,  GGGCGGR_SP1_Q6 ,  AP1_Q2_01 ,  GCGNNANTTCC_UNKNOWN ,  GAANYNYGACNY_UNKNOWN ,  E2F_03 ,  AP1_Q4 ,  GGCAGCT_MIR22 ,  FREAC2_01 ,  BACH1_01 ,  GR_01 ,  WTTGKCTG_UNKNOWN ,  ER_Q6_02 ,  TCF1P_Q6 ,  AP1_Q4_01 ,  FREAC4_01 ,  CACTTTG_MIR520G_MIR520H ,  GGGTGGRR_PAX4_03

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-208 ,  Predicted Gene Targets for miR-22 ,  Predicted Gene Targets for miR-499

miRNA binding sites
(Source: miRecords):

hsa-miR-21 Targeted Genes ,  [miR-106b] Targeted Genes ,  [miR-93] Targeted Genes

Cytogenetic Map:

6p21.2

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