QuickView for CDKN1C (gene)

Gene Symbol:

CDKN1C Homo sapiens

Full name:

cyclin dependent kinase inhibitor 1C

Synonyms:

BWCR, BWS, KIP2, WBS, p57, p57Kip2, cyclin-dependent kinase inhibitor 1C, cyclin-dependent kinase inhibitor 1C (p57, Kip2), cyclin-dependent kinase inhibitor p57

Genomic Location:

Chr 11: 2861441-2863551

Description:

This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor supp...

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This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

FOXO1_02 ,  RTAAACA_FREAC2_01 ,  CEBP_Q2_01 ,  SRY_01 ,  GTGCAAA_MIR507 ,  GTGCAAT_MIR25_MIR32_MIR92_MIR363_MIR367 ,  CEBP_Q2 ,  FOXO3_01 ,  FREAC3_01 ,  CAGGTG_E12_Q6 ,  E2F1_Q3_01 ,  FOXO1_01 ,  FREAC2_01 ,  TTGTTT_FOXO4_01 ,  CTTTGT_LEF1_Q2 ,  PAX4_03 ,  FOXO4_02 ,  ATGTAGC_MIR221_MIR222

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-221 ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-320 ,  Predicted Gene Targets for miR-363

miRNA binding sites
(Source: miRecords):

hsa-miR-221 Targeted Genes

Cytogenetic Map:

11p15.4

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