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QuickView for CDKN2B (gene)


Gene Symbol:
CDKN2B Homo sapiens Homo sapiens
Full name:
cyclin dependent kinase inhibitor 2B
Synonyms:
CDK4I, INK4B, MTS2, P15, TP15, p15INK4b, cyclin-dependent kinase 4 inhibitor B, CDK inhibitory protein, CDK4B inhibitor, MTS-2, cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4), cyclin-dependent kinases 4 and 6 binding protein, multiple tumor suppressor 2, p14-INK4b, p14_CDK inhibitor, p14_INK4B, p15 CDK inhibitor, p15-INK4b, p15_INK4B
Genomic Location:
Chr 9: 21992902-21999312
Description:
This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Pan troglodytes Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 9
9p21.3


Transcripts Names
NM_004936
NM_078487
Protein Names
K7PPU3
Q6FI09
O15125
P42772



GO Molecular Function

kinase binding | protein kinase regulator activity | protein serine/threonine kinase inhibitor activity | kinase regulator activity | protein kinase inhibitor activity | protein kinase binding | enzyme binding | enzyme inhibitor activity | molecular function regulator | protein binding | kinase inhibitor activity | enzyme regulator activity | cyclin-dependent protein serine/threonine kinase inhibitor activity | cyclin-dependent protein serine/threonine kinase regulator activity

GO Biological Process

response to extracellular stimulus | negative regulation of phosphorylation | regulation of cell cycle process | positive regulation of macromolecule biosynthetic process | response to nutrient levels | regulation of cell cycle G1/S phase transition | protein kinase regulator activity | myeloid cell differentiation | regulation of transforming growth factor beta receptor signaling pathway | negative regulation of cellular process | negative regulation of kinase activity | cell differentiation | protein serine/threonine kinase inhibitor activity | cellular response to extracellular stimulus | negative regulation of protein phosphorylation | regulation of G1/S transition of mitotic cell cycle | positive regulation of cellular biosynthetic process | cellular process | negative regulation of G1/S transition of mitotic cell cycle | kinase regulator activity | protein kinase inhibitor activity | immune system development | regulation of cell cycle | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | regulation of cellular process | regulation of metabolic process | response to stimulus | enzyme inhibitor activity | regulation of mitotic cell cycle phase transition | negative regulation of protein kinase activity | regulation of cell proliferation | regulation of cell cycle phase transition | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | hemopoiesis | molecular function regulator | regulation of nucleic acid-templated transcription | system development | regulation of cyclin-dependent protein serine/threonine kinase activity | cellular response to nutrient levels | regulation of signal transduction | negative regulation of mitotic cell cycle phase transition | negative regulation of phosphate metabolic process | multicellular organism development | negative regulation of catalytic activity | spleen development | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | regulation of gene expression | cell cycle | negative regulation of cyclin-dependent protein serine/threonine kinase activity | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | negative regulation of protein serine/threonine kinase activity | regulation of transcription by RNA polymerase II | response to nutrient | regulation of cellular protein metabolic process | G2/M transition of mitotic cell cycle | megakaryocyte differentiation | mitotic cell cycle phase transition | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of protein metabolic process | positive regulation of signal transduction | cell cycle G2/M phase transition | regulation of protein phosphorylation | regulation of RNA metabolic process | regulation of cellular response to growth factor stimulus | regulation of mitotic cell cycle | negative regulation of cyclin-dependent protein kinase activity | negative regulation of epithelial cell proliferation | cellular response to nutrient | cell cycle arrest | kinase inhibitor activity | regulation of kinase activity | anatomical structure development | mitotic cell cycle | regulation of RNA biosynthetic process | negative regulation of mitotic cell cycle | animal organ development | negative regulation of cellular protein metabolic process | regulation of phosphate metabolic process | negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle | negative regulation of cell cycle | negative regulation of protein metabolic process | positive regulation of transforming growth factor beta receptor signaling pathway | regulation of cell communication | negative regulation of cell cycle G1/S phase transition | negative regulation of molecular function | regulation of transcription, DNA-templated | regulation of epithelial cell proliferation | enzyme regulator activity | developmental process | cyclin-dependent protein serine/threonine kinase inhibitor activity | positive regulation of transcription, DNA-templated | negative regulation of cell proliferation | positive regulation of nucleic acid-templated transcription | cell cycle phase transition | positive regulation of transcription by RNA polymerase II | positive regulation of metabolic process | immune system process | mitotic cell cycle checkpoint | hematopoietic or lymphoid organ development | negative regulation of cell cycle process | cell cycle checkpoint | positive regulation of signaling | regulation of signaling | positive regulation of gene expression | cyclin-dependent protein serine/threonine kinase regulator activity | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

intracellular membrane-bounded organelle | cell | cytoplasm | intracellular organelle | membrane-bounded organelle | nucleus | organelle | cytosol | intracellular