QuickView for CDKN3 (gene)
- Gene Symbol:
- CDKN3
Homo sapiens - Full name:
- cyclin dependent kinase inhibitor 3
- Synonyms:
- CDI1, CIP2, KAP, KAP1, cyclin-dependent kinase inhibitor 3, CDK2-associated dual specificity phosphatase, Cdk-associated protein phosphatase, cyclin-dependent kinase inhibitor, cyclin-dependent kinase interacting protein 2, cyclin-dependent kinase interactor 1, kinase-associated phosphatase
- Genomic Location:
- Chr 14: 53933476-53956682
- Description:
-
The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of c...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
14q22.2
GO Molecular Function
protein serine/threonine phosphatase activity | phosphatase activity | protein tyrosine/serine/threonine phosphatase activity | hydrolase activity | protein tyrosine phosphatase activity | catalytic activity | phosphoprotein phosphatase activity | hydrolase activity, acting on ester bonds | protein binding | phosphoric ester hydrolase activity
GO Biological Process
protein serine/threonine phosphatase activity | protein dephosphorylation | negative regulation of cellular process | cellular process | regulation of cell cycle | regulation of cellular process | regulation of metabolic process | phosphatase activity | protein tyrosine/serine/threonine phosphatase activity | regulation of cell proliferation | cell cycle G1/S phase transition | protein modification process | macromolecule modification | protein tyrosine phosphatase activity | regulation of cyclin-dependent protein serine/threonine kinase activity | nitrogen compound metabolic process | phosphorus metabolic process | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | cell cycle | phosphoprotein phosphatase activity | regulation of nitrogen compound metabolic process | regulation of cellular protein metabolic process | mitotic cell cycle phase transition | phosphate-containing compound metabolic process | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of protein metabolic process | G1/S transition of mitotic cell cycle | regulation of protein phosphorylation | protein metabolic process | cell cycle arrest | regulation of kinase activity | mitotic cell cycle | metabolic process | organic substance metabolic process | regulation of phosphate metabolic process | negative regulation of cell cycle | dephosphorylation | cellular protein metabolic process | cellular protein modification process | negative regulation of cell proliferation | peptidyl-tyrosine dephosphorylation | cell cycle phase transition | cellular metabolic process | macromolecule metabolic process | regulation of phosphorus metabolic process
GO Cellular Component
cell | cytoplasm | perinuclear region of cytoplasm | cytosol | intracellular
