QuickView for CDKN4 (gene)

Gene Symbol:

CDKN1B Homo sapiens

Full name:

cyclin dependent kinase inhibitor 1B

Synonyms:

CDKN4, KIP1, MEN1B, MEN4, P27KIP1, cyclin-dependent kinase inhibitor 1B, cyclin-dependent kinase inhibitor 1B (p27, Kip1)

Genomic Location:

Chr 12: 12761576-12766570

Description:

This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent pho...

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This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4).

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

PR_Q2 ,  RTAAACA_FREAC2_01 ,  GCATTTG_MIR105 ,  ZIC1_01 ,  SRF_Q6 ,  GCAAGGA_MIR502 ,  GCANCTGNY_MYOD_Q6 ,  TGTGTGA_MIR377 ,  GR_Q6_01 ,  GCCATNTTG_YY1_Q6 ,  E2F1_Q4 ,  CREB_Q3 ,  SOX9_B1 ,  TAATGTG_MIR323 ,  ETS2_B ,  ACTACCT_MIR196A_MIR196B ,  GGGCGGR_SP1_Q6 ,  AREB6_01 ,  CEBPB_02 ,  SRF_Q4 ,  AHR_Q5 ,  GCCNNNWTAAR_UNKNOWN ,  TTGTTT_FOXO4_01 ,  AP4_Q6_01 ,  IK2_01 ,  WTTGKCTG_UNKNOWN ,  CTGAGCC_MIR24 ,  GTGGGTGK_UNKNOWN ,  SRF_Q5_01 ,  AAGCACT_MIR520F ,  AP1_Q2 ,  CAGCTG_AP4_Q5 ,  FOXM1_01 ,  AGGCACT_MIR5153P ,  CEBPGAMMA_Q6 ,  ACATATC_MIR190 ,  GGGTGGRR_PAX4_03 ,  TAXCREB_01 ,  ATGTAGC_MIR221_MIR222 ,  LBP1_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-148 ,  Predicted Gene Targets for miR-186 ,  Predicted Gene Targets for miR-190 ,  Predicted Gene Targets for miR-194 ,  Predicted Gene Targets for miR-196 ,  Predicted Gene Targets for miR-221 ,  Predicted Gene Targets for miR-24 ,  Predicted Gene Targets for miR-323 ,  Predicted Gene Targets for miR-455

miRNA binding sites
(Source: miRecords):

hsa-miR-221 Targeted Genes ,  hsa-miR-222 Targeted Genes

Cytogenetic Map:

12p13.1

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