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QuickView for CDW44 (gene)


Gene Symbol:
CD44 Homo sapiens Homo sapiens
Full name:
CD44 molecule (Indian blood group)
Synonyms:
CDW44, CSPG8, ECMR-III, HCELL, HUTCH-I, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1, CD44 antigen, GP90 lymphocyte homing/adhesion receptor, Hermes antigen, cell surface glycoprotein CD44, chondroitin sulfate proteoglycan 8, epican, extracellular matrix receptor III, hematopoietic cell E- and L-selectin ligand, heparan sulfate proteoglycan, homing function and Indian blood group system, hyaluronate receptor, phagocytic glycoprotein 1, soluble CD44
Genomic Location:
Chr 11: 35116993-35210525
Description:
The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions i...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
miRNA binding sites
(Source: miRecords):
Cytogenetic Map:
chr 11
11p13





GO Molecular Function

transmembrane signaling receptor activity | carboxylic acid binding | protein-containing complex binding | hyaluronic acid binding | carbohydrate derivative binding | anion binding | collagen binding | signaling receptor activity | ion binding | cytokine receptor activity | protein binding | glycosaminoglycan binding | organic acid binding | small molecule binding

GO Biological Process

regulation of ERK1 and ERK2 cascade | regulation of cysteine-type endopeptidase activity | exocytosis | extracellular structure organization | response to cytokine | cell motility | regulation of cell morphogenesis | neutrophil activation | cell-substrate adhesion | morphogenesis of an epithelium | regulation of programmed cell death | positive regulation of peptidyl-tyrosine phosphorylation | negative regulation of cysteine-type endopeptidase activity | establishment of localization | negative regulation of cellular process | defense response | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | negative regulation of proteolysis | cellular process | secretion | organic substance catabolic process | leukocyte degranulation | localization | regulation of DNA damage response, signal transduction by p53 class mediator | negative regulation of signaling | positive regulation of peptidyl-serine phosphorylation | carbohydrate derivative catabolic process | positive regulation of heterotypic cell-cell adhesion | negative regulation of apoptotic process | glycosaminoglycan catabolic process | regulation of proteolysis | response to growth factor | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | tissue development | negative regulation of apoptotic signaling pathway | regulation of cellular process | leukocyte activation | regulation of apoptotic process | regulation of metabolic process | interferon-gamma-mediated signaling pathway | catabolic process | positive regulation of cellular protein metabolic process | epithelium development | cellular component organization | cellular response to interferon-gamma | response to stimulus | wound healing, spreading of cells | neutrophil degranulation | cellular response to fibroblast growth factor stimulus | regulation of peptidyl-tyrosine phosphorylation | positive regulation of protein metabolic process | carboxylic acid catabolic process | leukocyte aggregation | response to stress | regulation of heterotypic cell-cell adhesion | leukocyte activation involved in immune response | positive regulation of cell-cell adhesion | secretion by cell | extracellular matrix organization | negative regulation of metabolic process | cartilage development | regulation of cell adhesion | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage | negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator | epiboly | leukocyte migration | monocyte aggregation | regulation of cellular response to stress | locomotion | system development | nitrogen compound metabolic process | regulation of signal transduction | multicellular organism development | negative regulation of catalytic activity | cell migration | regulation of peptidase activity | regulation of MAPK cascade | leukocyte mediated immunity | regulation of catalytic activity | regulation of phosphorylation | regulation of intrinsic apoptotic signaling pathway | hyaluronan metabolic process | negative regulation of peptidase activity | wound healing | regulation of signal transduction by p53 class mediator | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of nitrogen compound metabolic process | negative regulation of signal transduction by p53 class mediator | regulation of cysteine-type endopeptidase activity involved in apoptotic process | small molecule metabolic process | cytokine-mediated signaling pathway | positive regulation of intracellular signal transduction | vesicle-mediated transport | morphogenesis of an epithelial sheet | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | cellular response to cytokine stimulus | regulation of cellular protein metabolic process | regulated exocytosis | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | regulation of apoptotic signaling pathway | cytokine receptor activity | cell communication | regulation of cellular metabolic process | inflammatory response | cell activation involved in immune response | myeloid cell activation involved in immune response | regulation of protein metabolic process | positive regulation of signal transduction | neutrophil activation involved in immune response | regulation of protein phosphorylation | regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | carboxylic acid metabolic process | positive regulation of protein modification process | response to organic substance | tissue morphogenesis | response to wounding | negative regulation of DNA damage response, signal transduction by p53 class mediator | positive regulation of monocyte aggregation | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | anatomical structure development | cell surface receptor signaling pathway | leukocyte cell-cell adhesion | metabolic process | negative regulation of programmed cell death | cell adhesion | regulation of response to DNA damage stimulus | immune response | organic substance metabolic process | connective tissue development | negative regulation of intrinsic apoptotic signaling pathway | regulation of intrinsic apoptotic signaling pathway in response to DNA damage | animal organ development | negative regulation of cellular protein metabolic process | positive regulation of ERK1 and ERK2 cascade | regulation of phosphate metabolic process | cell-cell adhesion | response to interferon-gamma | cell activation | positive regulation of MAPK cascade | regulation of peptidyl-serine phosphorylation | negative regulation of protein metabolic process | organonitrogen compound catabolic process | regulation of cell communication | negative regulation of molecular function | negative regulation of signal transduction | signaling | cell-matrix adhesion | organic acid metabolic process | positive regulation of phosphorylation | anatomical structure morphogenesis | regulation of endopeptidase activity | regulation of developmental process | regulation of intrinsic apoptotic signaling pathway by p53 class mediator | developmental process | carbohydrate derivative metabolic process | regulation of cell-cell adhesion | innate immune response | response to fibroblast growth factor | regulation of lamellipodium morphogenesis | neutrophil mediated immunity | negative regulation of hydrolase activity | positive regulation of metabolic process | regulation of cell projection organization | skeletal system development | immune system process | cellular metabolic process | cellular response to organic substance | regulation of cell death | negative regulation of cell death | positive regulation of leukocyte cell-cell adhesion | extracellular matrix disassembly | regulation of cellular component organization | positive regulation of signaling | signal transduction | regulation of signaling | negative regulation of endopeptidase activity | hyaluronan catabolic process | cellular response to growth factor stimulus | glycosaminoglycan metabolic process | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

secretory granule | integral component of membrane | intracellular membrane-bounded organelle | apical plasma membrane | adherens junction | organelle membrane | cell projection membrane | focal adhesion | cytoplasmic vesicle | actin-based cell projection | cell | intrinsic component of membrane | lamellipodium | cytoplasm | cell-substrate junction | intracellular organelle | receptor complex | secretory granule membrane | leading edge membrane | apical part of cell | Golgi apparatus | protein-containing complex | cell projection | secretory vesicle | endomembrane system | plasma membrane | cell leading edge | vesicle | extracellular exosome | integral component of plasma membrane | extracellular region | microvillus | membrane-bounded organelle | extracellular vesicle | macrophage migration inhibitory factor receptor complex | organelle | vesicle membrane | extracellular space | cell periphery | basolateral plasma membrane | cell-substrate adherens junction | cytosol | intracellular vesicle | cell surface | intracellular | cell junction | membrane | cytoplasmic vesicle membrane | lamellipodium membrane | intrinsic component of plasma membrane