QuickView for CDX1;jsessionid=4B060BFA8360CF4DB9F66BDFB7C74DC7 (gene)
- Gene Symbol:
- CDX1
Homo sapiens - Full name:
- caudal type homeobox 1
- Synonyms:
- homeobox protein CDX-1, caudal type homeo box transcription factor 1, caudal type homeobox transcription factor 1, caudal-type homeobox protein 1, caudal-type homeobox protein CDX1
- Genomic Location:
- Chr 5: 149526537-149544314
- Description:
-
This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded DNA-binding protein regulates intestine-specific gene expression and enterocyte differentiation. It has been shown to induce expression of the intestinal alkaline phosphatase gene, and inhibit beta-catenin/T-cell factor transcriptional activity.
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Danio rerio , Gallus gallus , Pan troglodytes , Bos taurus , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
OCT1_05 , CATTGTYY_SOX9_B1 , VDR_Q6 , ARP1_01 , CTTTGA_LEF1_Q2 , IRF1_Q6 , COUP_01 , E2F1_Q4 , TCF4_Q5 , HNF4_DR1_Q3
- Cytogenetic Map:
-
5q32
GO Molecular Function
sequence-specific DNA binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | enhancer binding | nucleic acid binding | nucleotide binding | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding | enhancer sequence-specific DNA binding | RNA polymerase II regulatory region DNA binding | DNA binding | sequence-specific double-stranded DNA binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | RNA polymerase II regulatory region sequence-specific DNA binding | RNA polymerase II distal enhancer sequence-specific DNA binding | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | methyl-CpG binding | heterocyclic compound binding | small molecule binding
GO Biological Process
RNA metabolic process | transcription by RNA polymerase II | positive regulation of macromolecule biosynthetic process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | bone development | cell differentiation | positive regulation of cellular biosynthetic process | cellular process | regulation of embryonic development | positive regulation of nitrogen compound metabolic process | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding | cellular nitrogen compound biosynthetic process | cellular nitrogen compound metabolic process | positive regulation of RNA biosynthetic process | cellular biosynthetic process | regulation of nucleic acid-templated transcription | system development | nitrogen compound metabolic process | multicellular organism development | regulation of gene expression | positive regulation of cellular metabolic process | animal organ morphogenesis | regulation of nitrogen compound metabolic process | regulation of somitogenesis | regulation of transcription by RNA polymerase II | biosynthetic process | aromatic compound biosynthetic process | regulation of cellular metabolic process | skeletal system morphogenesis | bone morphogenesis | regulation of RNA metabolic process | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | anatomical structure development | metabolic process | regulation of RNA biosynthetic process | nucleobase-containing compound metabolic process | organic substance metabolic process | animal organ development | gene expression | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | transcription, DNA-templated | regulation of transcription, DNA-templated | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | regulation of developmental process | developmental process | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | positive regulation of metabolic process | skeletal system development | cellular metabolic process | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
intracellular membrane-bounded organelle | cell | intracellular organelle | membrane-bounded organelle | nucleus | organelle | intracellular
