QuickView for CDw197 (gene)

Gene Symbol:

CCR7 Homo sapiens

Full name:

C-C motif chemokine receptor 7

Synonyms:

BLR2, CC-CKR-7, CCR-7, CD197, CDw197, CMKBR7, EBI1, C-C chemokine receptor type 7, Bukitt's lymphoma receptor 2, CC chemokine receptor 7, EBV-induced G protein-coupled receptor 1, Epstein-Barr virus induced gene 1, Epstein-Barr virus-induced G-protein coupled receptor 1, MIP-3 beta receptor, chemokine (C-C motif) receptor 7, lymphocyte-specific G protein-coupled peptide receptor

Genomic Location:

Chr 17: 35963547-35975250

Description:

The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control...

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The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis. Alternative splicing of this gene results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

SMTTTTGT_UNKNOWN ,  TGANTCA_AP1_C ,  WGTTNNNNNAAA_UNKNOWN ,  CTTTGA_LEF1_Q2 ,  IRF1_Q6 ,  GGGAGGRR_MAZ_Q6 ,  CTACCTC_LET7A_LET7B_LET7C_LET7D_LET7E_LET7F_MIR98_LET7G_LET7I ,  TATA_C ,  MGGAAGTG_GABP_B ,  CTTTAAR_UNKNOWN ,  GFI1_01 ,  RGAGGAARY_PU1_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for let-7

Cytogenetic Map:

17q21.2

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