QuickView for CEBPA;jsessionid=DF3FB09F3D48514796170E68146687DE (gene)

Gene Symbol:

CEBPA Homo sapiens

Full name:

CCAAT/enhancer binding protein alpha

Synonyms:

C/EBP-alpha, CEBP, CCAAT/enhancer-binding protein alpha, CCAAT/enhancer binding protein (C/EBP), alpha

Genomic Location:

Chr 19: 38482776-38485160

Description:

This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes i...

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This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. Mutation of this gene is associated with acute myeloid leukemia. The use of alternative in-frame non-AUG (GUG) and AUG start codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the GUG and the first AUG start codons.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CTTGTAT_MIR381 ,  CCCAGAG_MIR326 ,  TTANTCA_UNKNOWN ,  FOX_Q2 ,  HFH3_01 ,  CACGTG_MYC_Q2 ,  YATTNATC_UNKNOWN ,  GTACTGT_MIR101 ,  MYCMAX_B ,  GTGCAAT_MIR25_MIR32_MIR92_MIR363_MIR367 ,  TATCTGG_MIR488 ,  MYCMAX_01 ,  GGGCGGR_SP1_Q6 ,  GTGCCTT_MIR506 ,  TTGCCAA_MIR182 ,  AAACCAC_MIR140 ,  ACCATTT_MIR522

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-144 ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-299 ,  Predicted Gene Targets for miR-326 ,  Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-96 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-140 ,  Predicted Gene Targets for miR-182 ,  Predicted Gene Targets for miR-31 ,  Predicted Gene Targets for miR-488

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miRNA binding sites
(Source: miRecords):

hsa-miR-124 Targeted Genes

Cytogenetic Map:

19q13.11

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