QuickView for CFL (gene)

Gene Symbol:

CFL1 Homo sapiens

Full name:

cofilin 1

Synonyms:

CFL, HEL-S-15, cofilin, cofilin-1, 18 kDa phosphoprotein, cofilin 1 (non-muscle), cofilin, non-muscle isoform, epididymis secretory protein Li 15, p18

Genomic Location:

Chr 11: 65378858-65382380

Description:

The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin a...

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The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Danio rerio ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

E12_Q6 ,  MYOD_Q6_01 ,  CGGAARNGGCNG_UNKNOWN ,  SRF_01 ,  MYOD_01 ,  MYC_Q2 ,  CACGTG_MYC_Q2 ,  SRF_Q6 ,  MAX_01 ,  GGAMTNNNNNTCCY_UNKNOWN ,  E2A_Q2 ,  EGR2_01 ,  GGGAGGRR_MAZ_Q6 ,  CAGGTG_E12_Q6 ,  ATGCTGC_MIR103_MIR107 ,  GGGCGGR_SP1_Q6 ,  SRF_Q4 ,  AHR_Q5 ,  ACTAYRNNNCCCR_UNKNOWN ,  E47_01 ,  CAGCAGG_MIR370 ,  NRF1_Q6 ,  TTGCCAA_MIR182 ,  YGCGYRCGC_UNKNOWN ,  WWTAAGGC_UNKNOWN ,  CTGCAGY_UNKNOWN ,  SRF_Q5_01 ,  RCGCANGCGY_NRF1_Q6 ,  USF2_Q6 ,  SRF_C ,  GGGTGGRR_PAX4_03

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-103 ,  Predicted Gene Targets for miR-370 ,  Predicted Gene Targets for miR-96 ,  Predicted Gene Targets for miR-182

Cytogenetic Map:

11q13.1

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