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QuickView for CHC17 (gene)


Gene Symbol:
CLTC Homo sapiens Homo sapiens
Full name:
clathrin heavy chain
Synonyms:
CHC, CHC17, CLH-17, CLTCL2, Hc, clathrin heavy chain 1, clathrin heavy chain on chromosome 17, clathrin, heavy polypeptide (Hc), clathrin, heavy polypeptide-like 2
Genomic Location:
Chr 17: 55051832-55129099
Description:
Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and thre...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Saccharomyces cerevisiae Macaca mulatta Schizosaccharomyces pombe Bos taurus Danio rerio Gallus gallus Pan troglodytes Canis lupus familiaris
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 17
17q23.1





GO Molecular Function

structural molecule activity | kinase binding | peptide binding | low-density lipoprotein particle receptor binding | clathrin binding | protein kinase binding | enzyme binding | nucleic acid binding | lipoprotein particle receptor binding | disordered domain specific binding | signaling receptor binding | ubiquitin-specific protease binding | protein domain specific binding | cytoskeletal protein binding | clathrin light chain binding | amide binding | identical protein binding | ankyrin binding | organic cyclic compound binding | protein binding | arrestin family protein binding | protease binding | heat shock protein binding | heterocyclic compound binding | RNA binding | double-stranded RNA binding

GO Biological Process

regulation of cell cycle process | antigen processing and presentation | transferrin transport | regulation of cellular localization | regulation of localization | regulation of carbohydrate metabolic process | establishment of localization | negative regulation of cellular process | regulation of protein localization to membrane | cell differentiation | regulation of organelle organization | membrane organization | intracellular transport | cellular process | organic substance catabolic process | localization | protein transport | metal ion transport | negative regulation of protein localization to plasma membrane | macromolecule localization | transition metal ion transport | regulation of cell cycle | regulation of mitotic spindle organization | establishment of localization in cell | negative regulation of cellular metabolic process | cytosolic transport | regulation of cellular process | regulation of metabolic process | catabolic process | low-density lipoprotein receptor particle metabolic process | regulation of establishment of planar polarity | cellular component organization | response to stimulus | regulation of cellular protein localization | endosomal transport | intracellular protein transport | regulation of plasma lipoprotein particle levels | cellular protein catabolic process | cellular localization | antigen processing and presentation of exogenous peptide antigen via MHC class II | negative regulation of metabolic process | cellular component assembly | Wnt signaling pathway, planar cell polarity pathway | cell-cell signaling | cell surface receptor signaling pathway involved in cell-cell signaling | nitrogen compound metabolic process | Wnt signaling pathway | antigen processing and presentation of peptide antigen via MHC class II | negative regulation of cellular protein localization | transcytosis | organic substance transport | cell cycle | protein catabolic process | regulation of nitrogen compound metabolic process | peptide transport | vesicle-mediated transport | non-canonical Wnt signaling pathway | cell division | cellular protein-containing complex assembly | plasma lipoprotein particle clearance | autophagy | cell communication | regulation of cellular metabolic process | receptor internalization | ferric iron transport | negative regulation of hyaluronan biosynthetic process | regulation of hyaluronan biosynthetic process | regulation of mitotic cell cycle | regulation of microtubule-based process | antigen processing and presentation of exogenous antigen | protein-containing complex assembly | negative regulation of carbohydrate metabolic process | protein metabolic process | receptor catabolic process | regulation of animal organ morphogenesis | import into cell | cellular macromolecule catabolic process | mitotic cell cycle | cell surface receptor signaling pathway | metabolic process | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II | clathrin coat assembly | regulation of protein localization to plasma membrane | cellular protein localization | amide transport | endocytosis | clathrin-dependent endocytosis | organic substance metabolic process | negative regulation of biosynthetic process | retrograde transport, endosome to Golgi | establishment of protein localization | organonitrogen compound catabolic process | signaling | protein localization | cellular protein metabolic process | cation transport | cellular macromolecule localization | iron ion transport | regulation of developmental process | receptor-mediated endocytosis | developmental process | receptor metabolic process | antigen processing and presentation of peptide antigen | ossification | osteoblast differentiation | ion transport | immune system process | cellular metabolic process | regulation of protein localization | low-density lipoprotein particle clearance | low-density lipoprotein particle receptor catabolic process | regulation of microtubule cytoskeleton organization | regulation of cellular component organization | regulation of cytoskeleton organization | signal transduction | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

supramolecular fiber | trans-Golgi network membrane | endolysosome | intracellular membrane-bounded organelle | sarcolemma | mitotic spindle microtubule | clathrin-coated endocytic vesicle membrane | endocytic vesicle membrane | clathrin-coated vesicle membrane | adherens junction | organelle membrane | vesicle coat | clathrin-coated vesicle | clathrin coat of coated pit | focal adhesion | cytoplasmic vesicle | Golgi-associated vesicle membrane | cell | plasma membrane protein complex | transport vesicle membrane | clathrin complex | microtubule | cytoplasm | clathrin-coated endocytic vesicle | spindle | cell-substrate junction | intracellular organelle | clathrin coat of trans-Golgi network vesicle | melanosome | endosome membrane | Golgi apparatus | protein-containing complex | endomembrane system | plasma membrane | Golgi-associated vesicle | vacuole | vesicle | transport vesicle | clathrin-coated pit | extracellular exosome | microtubule cytoskeleton | lytic vacuole | spindle microtubule | T-tubule | Golgi membrane | endosome | extracellular region | coated vesicle membrane | membrane-bounded organelle | extracellular vesicle | clathrin coat | organelle | vesicle membrane | lysosome | extracellular space | cell periphery | clathrin vesicle coat | trans-Golgi network | trans-Golgi network transport vesicle membrane | cell-substrate adherens junction | endolysosome membrane | trans-Golgi network transport vesicle | cytosol | intracellular vesicle | cytoskeleton | endocytic vesicle | intracellular | cell junction | mitotic spindle | lysosomal membrane | membrane | supramolecular complex | cytoplasmic vesicle membrane | membrane coat | vacuolar membrane | coated vesicle