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QuickView for CHDR (gene)


Gene Symbol:
AKR1C4 Homo sapiens Homo sapiens
Full name:
aldo-keto reductase family 1 member C4
Synonyms:
3-alpha-HSD, C11, CDR, CHDR, DD-4, DD4, HAKRA, aldo-keto reductase family 1 member C4, 3-alpha-HSD1, chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4, dihydrodiol dehydrogenase isozyme DD4, type I 3-alpha-hydroxysteroid dehydrogenase
Genomic Location:
Chr 10: 5228798-5250912
Description:
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme cata...
External Links:
Entrez Gene
Cytogenetic Map:
chr 10
10p15.1


Transcripts Names
NM_001818
Protein Names
Q5T6A3
Q8WW84
P17516
Q9NS54



GO Molecular Function

bile acid transmembrane transporter activity | oxidoreductase activity, acting on NAD(P)H | oxidoreductase activity, acting on CH-OH group of donors | steroid dehydrogenase activity | chlordecone reductase activity | organic anion transmembrane transporter activity | anion transmembrane transporter activity | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor | transmembrane transporter activity | ketosteroid monooxygenase activity | alcohol dehydrogenase (NADP+) activity | aldo-keto reductase (NADP) activity | organic acid transmembrane transporter activity | steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | catalytic activity | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | monooxygenase activity | electron transfer activity | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen | transporter activity | ion transmembrane transporter activity | alditol:NADP+ 1-oxidoreductase activity | androsterone dehydrogenase activity | carboxylic acid transmembrane transporter activity | retinal dehydrogenase activity | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor | monocarboxylic acid transmembrane transporter activity | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | lipid transporter activity | oxidoreductase activity

GO Biological Process

bile acid transmembrane transporter activity | oxidoreductase activity, acting on NAD(P)H | oxidoreductase activity, acting on CH-OH group of donors | steroid dehydrogenase activity | lipid transport | chlordecone reductase activity | organic anion transmembrane transporter activity | establishment of localization | response to hormone | anion transmembrane transporter activity | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor | generation of precursor metabolites and energy | bile acid biosynthetic process | cellular process | monocarboxylic acid transport | localization | anion transport | macromolecule localization | transmembrane transporter activity | ketosteroid monooxygenase activity | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | steroid biosynthetic process | cellular lipid metabolic process | alcohol dehydrogenase (NADP+) activity | response to stimulus | monocarboxylic acid metabolic process | alcohol metabolic process | aldo-keto reductase (NADP) activity | electron transport chain | organic acid transmembrane transporter activity | steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | organic hydroxy compound transport | androgen metabolic process | cofactor metabolic process | cellular biosynthetic process | carboxylic acid transmembrane transport | organic hydroxy compound metabolic process | cellular response to hormone stimulus | retinoid metabolic process | nitrogen compound metabolic process | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | monooxygenase activity | antibiotic metabolic process | lipid metabolic process | regulation of hormone levels | ion transmembrane transport | electron transfer activity | organic substance transport | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen | small molecule metabolic process | daunorubicin metabolic process | organic acid transport | ion transmembrane transporter activity | cellular ketone metabolic process | biosynthetic process | alditol:NADP+ 1-oxidoreductase activity | androsterone dehydrogenase activity | organic anion transport | lipid biosynthetic process | carboxylic acid transmembrane transporter activity | drug metabolic process | carboxylic acid metabolic process | bile acid metabolic process | response to organic substance | progesterone metabolic process | retinal dehydrogenase activity | anion transmembrane transport | organic acid transmembrane transport | metabolic process | lipid localization | oxidation-reduction process | bile acid and bile salt transport | doxorubicin metabolic process | prostaglandin metabolic process | glycoside metabolic process | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor | organic substance metabolic process | monocarboxylic acid transmembrane transporter activity | C21-steroid hormone metabolic process | diterpenoid metabolic process | fatty acid metabolic process | icosanoid metabolic process | steroid metabolic process | transmembrane transport | organic acid metabolic process | carboxylic acid transport | hormone metabolic process | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | isoprenoid metabolic process | carbohydrate derivative metabolic process | quinone metabolic process | lipid transporter activity | ion transport | cellular metabolic process | cellular response to organic substance | oxidoreductase activity | cellular response to jasmonic acid stimulus

GO Cellular Component

cell | cytoplasm | vesicle | extracellular exosome | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | extracellular space | cytosol | intracellular