Correlation Engine 2.0
Clear Search sequence regions
Bookmark Forward Export SNPs

QuickView for CHF2 (gene)


Gene Symbol:
HEY1 Homo sapiens Homo sapiens
Full name:
hes related family bHLH transcription factor with YRPW motif 1
Synonyms:
BHLHb31, CHF2, HERP2, HESR1, HRT-1, OAF1, hHRT1, hairy/enhancer-of-split related with YRPW motif protein 1, HES-related repressor protein 1, HES-related repressor protein 2, basic helix-loop-helix protein OAF1, cardiovascular helix-loop-helix factor 2, class B basic helix-loop-helix protein 31, hairy and enhancer of split-related protein 1, hairy-related transcription factor 1, hairy/enhancer-of-split related with YRPW motif 1
Genomic Location:
Chr 8: 80838800-80842653
Description:
This gene encodes a nuclear protein belonging to the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcriptional repressors. Expression of this gene is induced by the Notch and c-Jun signal transduction pathways. Two similar and redundant genes in mouse are required for embryonic cardiovascular developmen...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Canis lupus familiaris Bos taurus Gallus gallus Pan troglodytes Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 8
8q21.13





GO Molecular Function

sequence-specific DNA binding | satellite DNA binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | nucleic acid binding | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | RNA polymerase II regulatory region DNA binding | DNA binding | sequence-specific double-stranded DNA binding | transcription corepressor activity | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | organic cyclic compound binding | microsatellite binding | transcription regulatory region sequence-specific DNA binding | protein binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | transcription factor binding | protein dimerization activity | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | transcription coregulator activity | transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding | heterocyclic compound binding

GO Biological Process

RNA metabolic process | transcription by RNA polymerase II | Notch signaling pathway | positive regulation of macromolecule biosynthetic process | regulation of neurogenesis | developmental process involved in reproduction | atrioventricular valve formation | regulation of cell development | heart trabecula morphogenesis | smooth muscle cell differentiation | dorsal aorta development | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | negative regulation of RNA biosynthetic process | cell differentiation | endothelial cell differentiation | nervous system development | epithelial to mesenchymal transition | neurogenesis | pulmonary valve development | generation of neurons | mesenchyme development | blood vessel morphogenesis | positive regulation of cellular biosynthetic process | cellular process | heart morphogenesis | negative regulation of signaling | reproductive system development | negative regulation of nucleic acid-templated transcription | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | tissue development | regulation of binding | regulation of cell differentiation | muscle structure development | muscle cell differentiation | ventricular septum morphogenesis | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | trabecula morphogenesis | RNA biosynthetic process | epithelium development | cellular aromatic compound metabolic process | blood vessel endothelial cell differentiation | regulation of vasculature development | response to stimulus | vasculature development | cellular nitrogen compound biosynthetic process | heart trabecula formation | tube morphogenesis | regulation of transcription regulatory region DNA binding | reproduction | atrioventricular valve morphogenesis | cardiovascular system development | cardiac ventricle morphogenesis | cellular nitrogen compound metabolic process | regulation of DNA binding | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | cellular biosynthetic process | embryo development | embryonic placenta development | blood vessel development | pulmonary valve morphogenesis | regulation of nucleic acid-templated transcription | endocardial cushion development | system development | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | endothelium development | heart valve formation | multicellular organism development | umbilical cord morphogenesis | cardiac epithelial to mesenchymal transition | artery development | regulation of gene expression | endocardial cushion morphogenesis | positive regulation of cellular metabolic process | animal organ morphogenesis | regulation of nitrogen compound metabolic process | placenta blood vessel development | regulation of Notch signaling pathway | negative regulation of DNA binding | transcription corepressor activity | regulation of transcription by RNA polymerase II | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | negative regulation of binding | biosynthetic process | labyrinthine layer development | aromatic compound biosynthetic process | negative regulation of transcription regulatory region DNA binding | angiogenesis | mesenchyme morphogenesis | cardiac septum morphogenesis | labyrinthine layer blood vessel development | chordate embryonic development | cell communication | regulation of cellular metabolic process | semi-lunar valve development | heart development | embryo development ending in birth or egg hatching | regulation of RNA metabolic process | heart valve development | ventricular septum development | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | cardiac ventricle development | tissue morphogenesis | artery morphogenesis | anatomical structure development | cell surface receptor signaling pathway | aorta development | metabolic process | mesenchymal cell differentiation | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | embryonic organ development | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | nucleobase-containing compound metabolic process | heart valve morphogenesis | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | gene expression | dorsal aorta morphogenesis | regulation of vasculogenesis | atrioventricular valve development | transcription, DNA-templated | aorta morphogenesis | anatomical structure formation involved in morphogenesis | regulation of cell communication | negative regulation of molecular function | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | reproductive structure development | regulation of nervous system development | regulation of developmental process | developmental process | arterial endothelial cell differentiation | cardiac septum development | negative regulation of transcription by RNA polymerase II | tube development | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | transcription coregulator activity | epithelial cell differentiation | positive regulation of transcription by RNA polymerase II | cardiac chamber development | heterocycle metabolic process | transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding | in utero embryonic development | negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation | positive regulation of metabolic process | negative regulation of Notch signaling pathway | cellular metabolic process | placenta development | circulatory system development | signal transduction | regulation of signaling | Notch signaling involved in heart development | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

intracellular membrane-bounded organelle | cell | nuclear lumen | cytoplasm | intracellular organelle | nucleoplasm | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | intracellular