QuickView for CHKB (gene)

Gene Symbol:

CHKB Homo sapiens

Full name:

choline kinase beta

Synonyms:

CHETK, CHKL, CK, CKB, CKEKB, EK, EKB, MDCMC, choline/ethanolamine kinase, choline kinase-like protein, ethanolamine kinase beta

Genomic Location:

Chr 22: 49364253-49368260

Description:

Choline kinase (CK) and ethanolamine kinase (EK) catalyze the phosphorylation of choline/ethanolamine to phosphocholine/phosphoethanolamine. This is the first enzyme in the biosynthesis of phosphatidylcholine/phosphatidylethanolamine in all animal cells. The highly purified CKs from mammalian sources and their recombinant gene products have been sh...

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Choline kinase (CK) and ethanolamine kinase (EK) catalyze the phosphorylation of choline/ethanolamine to phosphocholine/phosphoethanolamine. This is the first enzyme in the biosynthesis of phosphatidylcholine/phosphatidylethanolamine in all animal cells. The highly purified CKs from mammalian sources and their recombinant gene products have been shown to have EK activity also, indicating that both activities reside on the same protein. The choline kinase-like protein encoded by CHKL belongs to the choline/ethanolamine kinase family; however, its exact function is not known. Read-through transcripts are expressed from this locus that include exons from the downstream CPT1B locus.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Bos taurus ,  Danio rerio ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GGGACCA_MIR133A_MIR133B ,  AACTGGA_MIR145 ,  ATGTACA_MIR493 ,  CACCAGC_MIR138 ,  GAGCCAG_MIR149 ,  PAX4_01 ,  TCCAGAG_MIR518C ,  CTCCAAG_MIR432

Cytogenetic Map:

22q13.33

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