QuickView for CHMP2A;jsessionid=E3140089D06F67708964EBBFAC0287D0 (gene)
- Gene Symbol:
- CHMP2A
Homo sapiens - Full name:
- charged multivesicular body protein 2A
- Synonyms:
- BC-2, BC2, CHMP2, VPS2, VPS2A, charged multivesicular body protein 2a, VPS2 homolog A, chromatin modifying protein 2A, putative breast adenocarcinoma marker (32kD), putative breast adenocarcinoma marker BC-2, vacuolar protein sorting-associated protein 2-1, vps2-1
- Genomic Location:
- Chr 19: 63754745-63758298
- Description:
-
CHMP2A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear a...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Saccharomyces cerevisiae , Macaca mulatta , Schizosaccharomyces pombe , Pan troglodytes , Canis lupus familiaris , Bos taurus , Gallus gallus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
19q13.43
GO Molecular Function
cation binding | lipid binding | phospholipid binding | protein domain specific binding | anion binding | phosphatidylcholine binding | ion binding | protein binding
GO Biological Process
positive regulation of exosomal secretion | protein homooligomerization | nucleus organization | regulation of cell cycle process | positive regulation of locomotion | regulation of localization | macroautophagy | establishment of localization | negative regulation of cellular process | regulation of organelle organization | membrane organization | intracellular transport | positive regulation of viral life cycle | cellular process | regulation of centriole replication | establishment of organelle localization | endosome transport via multivesicular body sorting pathway | viral budding via host ESCRT complex | localization | protein transport | regulation of mitotic nuclear division | macromolecule localization | endomembrane system organization | regulation of cell cycle | cell separation after cytokinesis | regulation of mitotic spindle organization | establishment of localization in cell | interspecies interaction between organisms | regulation of cellular process | catabolic process | organelle localization | negative regulation of centrosome duplication | regulation of viral release from host cell | cellular component organization | establishment of chromosome localization | viral life cycle | nuclear envelope reassembly | regulation of centrosome cycle | chromosome segregation | endosomal transport | negative regulation of centriole replication | vacuolar transport | exit from mitosis | cellular localization | nuclear envelope organization | cellular component assembly | regulation of mitotic spindle assembly | positive regulation of exocytosis | organelle assembly | regulation of exosomal secretion | positive regulation of viral process | sister chromatid segregation | protein complex oligomerization | positive regulation of secretion | organic substance transport | cell cycle | positive regulation of viral release from host cell | multivesicular body assembly | regulation of spindle assembly | mitotic metaphase plate congression | peptide transport | protein polymerization | vesicle-mediated transport | cell division | metaphase plate congression | cellular protein-containing complex assembly | mitotic cell cycle phase transition | autophagy | nuclear chromosome segregation | regulation of locomotion | positive regulation of transport | viral process | regulation of viral process | regulation of mitotic cell cycle | regulation of microtubule-based process | regulation of centrosome duplication | protein-containing complex assembly | regulation of exocytosis | viral budding | mitotic cell cycle | nuclear division | metabolic process | negative regulation of cytoskeleton organization | ESCRT complex disassembly | membrane invagination | virion assembly | amide transport | regulation of vesicle-mediated transport | regulation of secretion | multivesicular body organization | positive regulation of cellular component biogenesis | late endosome to vacuole transport | mitotic nuclear division | establishment of protein localization | vesicle organization | negative regulation of cell cycle | protein localization | protein-containing complex disassembly | protein heterooligomerization | endosome organization | negative regulation of centriole elongation | organelle organization | regulation of transport | cell cycle phase transition | ESCRT III complex disassembly | chromosome organization | cellular metabolic process | negative regulation of cell cycle process | regulation of cell death | regulation of organelle assembly | regulation of viral life cycle | negative regulation of cell death | mitotic sister chromatid segregation | regulation of microtubule cytoskeleton organization | regulation of cellular component organization | multivesicular body sorting pathway | regulation of cytoskeleton organization
GO Cellular Component
chromosome | intracellular membrane-bounded organelle | late endosome | organelle membrane | cytoplasmic vesicle | cell | late endosome membrane | multivesicular body | ESCRT III complex | cytoplasm | intracellular organelle | endosome membrane | protein-containing complex | endomembrane system | nuclear envelope | chromatin | vesicle | extracellular exosome | endosome | extracellular region | membrane-bounded organelle | extracellular vesicle | nucleus | organelle | extracellular space | cytosol | intracellular vesicle | intracellular | membrane | membrane coat
