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QuickView for CHRNA4 (gene)


Gene Symbol:
CHRNA4 Homo sapiens Homo sapiens
Full name:
cholinergic receptor nicotinic alpha 4 subunit
Synonyms:
BFNC, EBN, EBN1, NACHR, NACHRA4, NACRA4, neuronal acetylcholine receptor subunit alpha-4, cholinergic receptor, nicotinic alpha 4, cholinergic receptor, nicotinic, alpha 4 (neuronal), cholinergic receptor, nicotinic, alpha polypeptide 4, neuronal nicotinic acetylcholine receptor alpha-4 subunit
Genomic Location:
Chr 20: 61445109-61463192
Description:
This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membr...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Cytogenetic Map:
chr 20
20q13.33





GO Molecular Function

transmitter-gated ion channel activity | acetylcholine-gated cation-selective channel activity | neurotransmitter receptor activity | cation binding | passive transmembrane transporter activity | neurotransmitter binding | transmembrane signaling receptor activity | transmembrane transporter activity | ligand-gated ion channel activity | ion gated channel activity | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential | cation transmembrane transporter activity | acetylcholine receptor activity | signaling receptor activity | transporter activity | ion transmembrane transporter activity | extracellular ligand-gated ion channel activity | ion binding | acetylcholine binding | hormone binding | protein binding | excitatory extracellular ligand-gated ion channel activity | cation channel activity | inorganic cation transmembrane transporter activity | channel activity | drug binding | ion channel activity | substrate-specific channel activity

GO Biological Process

transmitter-gated ion channel activity | respiratory gaseous exchange | acetylcholine-gated cation-selective channel activity | regulation of localization | establishment of localization | response to hormone | excitatory postsynaptic potential | response to drug | cellular process | regulation of catecholamine secretion | localization | exploration behavior | passive transmembrane transporter activity | acetylcholine receptor signaling pathway | metal ion transport | chemical synaptic transmission | response to hypoxia | regulation of cellular process | leukocyte activation | transmembrane transporter activity | organic cyclic compound metabolic process | ligand-gated ion channel activity | cellular aromatic compound metabolic process | behavioral response to nicotine | response to stimulus | ion gated channel activity | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential | response to stress | regulation of response to drug | divalent metal ion transport | cellular nitrogen compound metabolic process | cell-cell signaling | cell surface receptor signaling pathway involved in cell-cell signaling | DNA repair | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential | regulation of membrane potential | response to nitrogen compound | cellular response to hormone stimulus | response to nicotine | response to oxygen levels | nitrogen compound metabolic process | cellular response to DNA damage stimulus | ion transmembrane transport | cellular response to ammonium ion | regulation of postsynaptic membrane potential | cellular response to stress | nervous system process | synaptic signaling | cation transmembrane transporter activity | response to ammonium ion | response to acetylcholine | response to oxidative stress | ion transmembrane transporter activity | cognition | B cell activation | locomotory behavior | sensory perception of pain | extracellular ligand-gated ion channel activity | response to toxic substance | cellular response to drug | cell communication | neuromuscular synaptic transmission | regulation of dopamine secretion | lymphocyte activation | cation transmembrane transport | inhibitory postsynaptic potential | response to organic substance | DNA metabolic process | cell surface receptor signaling pathway | metabolic process | calcium ion transport | regulation of secretion | behavior | membrane depolarization | nucleobase-containing compound metabolic process | organic substance metabolic process | excitatory extracellular ligand-gated ion channel activity | cell activation | cation channel activity | adult behavior | sensory perception | transmembrane transport | action potential | signaling | inorganic cation transmembrane transporter activity | cation transport | channel activity | regulation of ion transport | regulation of transport | synaptic transmission, cholinergic | heterocycle metabolic process | ion channel activity | ion transport | immune system process | cellular metabolic process | cellular response to organic substance | substrate-specific channel activity | signal transduction | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

integral component of membrane | dendrite | synapse | neuron projection | somatodendritic compartment | cell body | cell | neuronal cell body | plasma membrane protein complex | intrinsic component of membrane | synaptic membrane | external side of plasma membrane | receptor complex | dendritic tree | protein-containing complex | cell projection | postsynaptic membrane | postsynapse | plasma membrane | integral component of plasma membrane | cell periphery | transmembrane transporter complex | ion channel complex | cell surface | cell junction | acetylcholine-gated channel complex | membrane | intrinsic component of plasma membrane