QuickView for CHRNA5 (gene)
- Gene Symbol:
- CHRNA5
Homo sapiens - Full name:
- cholinergic receptor nicotinic alpha 5 subunit
- Synonyms:
- LNCR2, neuronal acetylcholine receptor subunit alpha-5, Cholinergic receptor, neuronal nicotinic, alpha polypeptide-5, acetylcholine receptor, nicotinic, alpha 5 (neuronal), cholinergic receptor, nicotinic alpha 5, cholinergic receptor, nicotinic, alpha 5 (neuronal), neuronal nicotinic acetylcholine receptor, alpha5 subunit
- Genomic Location:
- Chr 15: 76644961-76673515
- Description:
-
The protein encoded by this gene is a nicotinic acetylcholine receptor subunit and a member of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. These receptors are thought to be heteropentamers composed of separate but similar subunits. Defects in this gene have been linked to susceptibility to lung canc...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Bos taurus , Gallus gallus , Canis lupus familiaris , Danio rerio , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
15q25.1
GO Molecular Function
transmitter-gated ion channel activity | acetylcholine-gated cation-selective channel activity | neurotransmitter receptor activity | cation binding | passive transmembrane transporter activity | neurotransmitter binding | transmembrane signaling receptor activity | transmembrane transporter activity | ligand-gated ion channel activity | ion gated channel activity | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential | cation transmembrane transporter activity | acetylcholine receptor activity | signaling receptor activity | transporter activity | ion transmembrane transporter activity | extracellular ligand-gated ion channel activity | ion binding | acetylcholine binding | hormone binding | protein binding | excitatory extracellular ligand-gated ion channel activity | cation channel activity | inorganic cation transmembrane transporter activity | channel activity | drug binding | ion channel activity | substrate-specific channel activity
GO Biological Process
transmitter-gated ion channel activity | acetylcholine-gated cation-selective channel activity | establishment of localization | excitatory postsynaptic potential | response to drug | cellular process | localization | passive transmembrane transporter activity | chemical synaptic transmission | regulation of cellular process | transmembrane transporter activity | ligand-gated ion channel activity | behavioral response to nicotine | response to stimulus | ion gated channel activity | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential | cell-cell signaling | cell surface receptor signaling pathway involved in cell-cell signaling | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential | regulation of membrane potential | response to nicotine | ion transmembrane transport | regulation of postsynaptic membrane potential | nervous system process | synaptic signaling | cation transmembrane transporter activity | ion transmembrane transporter activity | extracellular ligand-gated ion channel activity | response to toxic substance | cell communication | neuromuscular synaptic transmission | cation transmembrane transport | cell surface receptor signaling pathway | behavior | excitatory extracellular ligand-gated ion channel activity | cation channel activity | adult behavior | transmembrane transport | signaling | inorganic cation transmembrane transporter activity | cation transport | channel activity | synaptic transmission, cholinergic | ion channel activity | ion transport | substrate-specific channel activity | signal transduction | multicellular organismal process
GO Cellular Component
integral component of membrane | synapse | neuron projection | cell | plasma membrane protein complex | intrinsic component of membrane | synaptic membrane | receptor complex | protein-containing complex | cell projection | postsynaptic membrane | postsynapse | plasma membrane | integral component of plasma membrane | cell periphery | transmembrane transporter complex | ion channel complex | cell junction | acetylcholine-gated channel complex | membrane | intrinsic component of plasma membrane
