QuickView for CHRNE (gene)

Gene Symbol:

CHRNE Homo sapiens

Full name:

cholinergic receptor nicotinic epsilon subunit

Synonyms:

ACHRE, CMS1D, CMS1E, CMS2A, CMS4A, CMS4B, CMS4C, FCCMS, SCCMS, acetylcholine receptor subunit epsilon, AchR epsilon subunit, acetylcholine receptor, nicotinic, epsilon (muscle), cholinergic receptor, nicotinic epsilon, cholinergic receptor, nicotinic, epsilon (muscle), cholinergic receptor, nicotinic, epsilon polypeptide

Genomic Location:

Chr 17: 4741840-4747148

Description:

Acetylcholine receptors at mature mammalian neuromuscular junctions are pentameric protein complexes composed of four subunits in the ratio of two alpha subunits to one beta, one epsilon, and one delta subunit. The acetylcholine receptor changes subunit composition shortly after birth when the epsilon subunit replaces the gamma subunit seen in embr...

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Acetylcholine receptors at mature mammalian neuromuscular junctions are pentameric protein complexes composed of four subunits in the ratio of two alpha subunits to one beta, one epsilon, and one delta subunit. The acetylcholine receptor changes subunit composition shortly after birth when the epsilon subunit replaces the gamma subunit seen in embryonic receptors. Mutations in the epsilon subunit are associated with congenital myasthenic syndrome.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GCANCTGNY_MYOD_Q6 ,  GGATTA_PITX2_Q2 ,  CAGGTG_E12_Q6 ,  MYOGENIN_Q6 ,  TGACAGNY_MEIS1_01 ,  CAGCTG_AP4_Q5 ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-142-3p ,  Predicted Gene Targets for miR-15

Cytogenetic Map:

17p13.2

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