QuickView for CLCK2 (gene)

Gene Symbol:

CLCN5 Homo sapiens

Full name:

chloride voltage-gated channel 5

Synonyms:

CLC5, CLCK2, ClC-5, DENTS, NPHL1, NPHL2, XLRH, XRN, hCIC-K2, H(+)/Cl(-) exchange transporter 5, chloride channel, voltage-sensitive 5, chloride transporter ClC-5, voltage-gated chloride ion channel CLCN5

Genomic Location:

Chr X: 49718955-49750632

Description:

This gene encodes a member of the ClC family of chloride ion channels and ion transporters. The encoded protein is primarily localized to endosomal membranes and may function to facilitate albumin uptake by the renal proximal tubule. Mutations in this gene have been found in Dent disease and renal tubular disorders complicated by nephrolithiasis. A...

View Full Description

This gene encodes a member of the ClC family of chloride ion channels and ion transporters. The encoded protein is primarily localized to endosomal membranes and may function to facilitate albumin uptake by the renal proximal tubule. Mutations in this gene have been found in Dent disease and renal tubular disorders complicated by nephrolithiasis. Alternatively spliced transcript variants have been found for this gene.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

HNF4ALPHA_Q6 ,  AGCYRWTTC_UNKNOWN ,  TGANTCA_AP1_C ,  TCANNTGAY_SREBP1_01 ,  TGANNYRGCA_TCF11MAFG_01 ,  E4BP4_01 ,  CTATGCA_MIR153 ,  TTGCACT_MIR130A_MIR301_MIR130B ,  GGTGAAG_MIR412 ,  GATA1_04 ,  ACTGTGA_MIR27A_MIR27B ,  TGAYRTCA_ATF3_Q6 ,  NFE2_01 ,  CAGGTA_AREB6_01 ,  ATF3_Q6 ,  ACTGAAA_MIR30A3P_MIR30E3P ,  TGCCAAR_NF1_Q6 ,  HLF_01 ,  TTGTTT_FOXO4_01 ,  ATATGCA_MIR448 ,  TGCTTTG_MIR330 ,  CTTTGT_LEF1_Q2 ,  PPAR_DR1_Q2 ,  TGACATY_UNKNOWN ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  USF_02

View More

View Less

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-130 ,  Predicted Gene Targets for miR-142-3p ,  Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-153 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-30-3p ,  Predicted Gene Targets for miR-330 ,  Predicted Gene Targets for miR-448 ,  Predicted Gene Targets for miR-149

Cytogenetic Map:

Xp11.23

search → result