QuickView for CLCN3 (gene)

Gene Symbol:

CLCN3 Homo sapiens

Full name:

chloride voltage-gated channel 3

Synonyms:

CLC3, ClC-3, H(+)/Cl(-) exchange transporter 3, chloride channel 3, chloride channel protein 3, chloride channel, voltage-sensitive 3, chloride transporter ClC-3

Genomic Location:

Chr 4: 170778297-170878732

Description:

This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catal...

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This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  GTGCCAT_MIR183 ,  CREBP1CJUN_01 ,  RYTTCCTG_ETS2_B ,  TGGNNNNNNKCCAR_UNKNOWN ,  GCANCTGNY_MYOD_Q6 ,  GTACTGT_MIR101 ,  ACTTTAT_MIR1425P ,  CREB_Q4 ,  ACTGTGA_MIR27A_MIR27B ,  OSF2_Q6 ,  TAATGTG_MIR323 ,  ACATTCC_MIR1_MIR206 ,  CAGGTA_AREB6_01 ,  ATF_01 ,  AATGTGA_MIR23A_MIR23B ,  CREB_Q2 ,  AACTTT_UNKNOWN ,  CREB_Q2_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-1 ,  Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-142-5p ,  Predicted Gene Targets for miR-153 ,  Predicted Gene Targets for miR-183 ,  Predicted Gene Targets for miR-23 ,  Predicted Gene Targets for miR-24 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-323 ,  Predicted Gene Targets for miR-433-3p ,  Predicted Gene Targets for miR-448 ,  Predicted Gene Targets for miR-539 ,  Predicted Gene Targets for miR-31

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miRNA binding sites
(Source: miRecords):

hsa-miR-1 Targeted Genes

Cytogenetic Map:

4q33

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