QuickView for CLOCK;jsessionid=E10958033198F1D4407FD5100F9BBB26 (gene)
- Gene Symbol:
- CLOCK
Homo sapiens - Full name:
- clock circadian regulator
- Synonyms:
- KAT13D, bHLHe8, circadian locomoter output cycles protein kaput, circadian locomoter output cycles kaput protein, class E basic helix-loop-helix protein 8, clock homolog
- Genomic Location:
- Chr 4: 55993417-56107754
- Description:
-
The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with ARNTL (BMAL1) that binds E-box enhancer elements upstream of Pe...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , Macaca mulatta , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
TTTGCAC_MIR19A_MIR19B , STAT4_01 , MAZR_01 , CEBPA_01 , HNF1_01 , GATA1_01 , ATGTCAC_MIR489 , CATTGTYY_SOX9_B1 , STAT6_02 , VDR_Q6
- miRNA binding sites
(Source: TargetScan): -
Predicted Gene Targets for miR-1 , Predicted Gene Targets for miR-130 , Predicted Gene Targets for miR-148 , Predicted Gene Targets for miR-15 , Predicted Gene Targets for miR-19 , Predicted Gene Targets for miR-190 , Predicted Gene Targets for miR-20 , Predicted Gene Targets for miR-30 , Predicted Gene Targets for miR-542-3p , Predicted Gene Targets for miR-9
- miRNA binding sites
(Source: miRecords):
- Cytogenetic Map:
-
4q12
GO Molecular Function
sequence-specific DNA binding | transcription factor activity, transcription factor binding | transcription regulatory region DNA binding | N-acetyltransferase activity | RNA polymerase II transcription factor activity, sequence-specific DNA binding | enhancer binding | transferase activity, transferring acyl groups other than amino-acyl groups | N-acyltransferase activity | transcription factor activity, RNA polymerase II transcription factor binding | proximal promoter sequence-specific DNA binding | nucleic acid binding | catalytic activity | chromatin binding | transferase activity, transferring acyl groups | enhancer sequence-specific DNA binding | histone acetyltransferase activity | RNA polymerase II regulatory region DNA binding | E-box binding | DNA binding | sequence-specific double-stranded DNA binding | organic cyclic compound binding | peptide N-acetyltransferase activity | transcription regulatory region sequence-specific DNA binding | protein binding | transcriptional activator activity, RNA polymerase II transcription factor binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | DNA-binding transcription factor activity | chromatin DNA binding | protein dimerization activity | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | RNA polymerase II distal enhancer sequence-specific DNA binding | transferase activity | peptide-lysine-N-acetyltransferase activity | acetyltransferase activity | heterocyclic compound binding
GO Biological Process
RNA metabolic process | transcription by RNA polymerase II | response to radiation | transcription factor activity, transcription factor binding | positive regulation of macromolecule biosynthetic process | proteolysis | regulation of cell development | regulation of localization | positive regulation of DNA-binding transcription factor activity | peptidyl-amino acid modification | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | negative regulation of RNA biosynthetic process | histone modification | male gamete generation | regulation of peptide hormone secretion | positive regulation of cellular biosynthetic process | cellular process | organic substance catabolic process | circadian regulation of gene expression | proteolysis involved in cellular protein catabolic process | chromatin organization | negative regulation of signaling | multicellular organismal reproductive process | negative regulation of nucleic acid-templated transcription | regulation of cell cycle | positive regulation of nitrogen compound metabolic process | transcription factor activity, RNA polymerase II transcription factor binding | negative regulation of cellular metabolic process | regulation of cell differentiation | gamete generation | regulation of cellular process | regulation of metabolic process | catabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | negative regulation of glucocorticoid receptor signaling pathway | cellular component organization | regulation of peptide secretion | response to stimulus | regulation of insulin secretion | response to stress | regulation of intracellular steroid hormone receptor signaling pathway | cellular nitrogen compound biosynthetic process | circadian rhythm | regulation of epithelial cell differentiation | reproduction | cellular protein catabolic process | peptidyl-lysine acetylation | rhythmic process | cellular nitrogen compound metabolic process | proteasomal protein catabolic process | regulation of protein transport | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | protein modification process | regulation of peptide transport | cellular biosynthetic process | macromolecule modification | regulation of nucleic acid-templated transcription | response to light stimulus | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | protein acetylation | positive regulation of inflammatory response | cellular response to DNA damage stimulus | regulation of hormone levels | regulation of hormone secretion | histone acetyltransferase activity | regulation of gene expression | cellular response to stress | protein catabolic process | positive regulation of cellular metabolic process | cellular response to radiation | regulation of nitrogen compound metabolic process | regulation of transcription by RNA polymerase II | negative regulation of intracellular steroid hormone receptor signaling pathway | histone acetylation | internal peptidyl-lysine acetylation | biosynthetic process | aromatic compound biosynthetic process | cell communication | regulation of cellular metabolic process | regulation of RNA metabolic process | proteasome-mediated ubiquitin-dependent protein catabolic process | positive regulation of molecular function | transcriptional activator activity, RNA polymerase II transcription factor binding | multicellular organism reproduction | protein metabolic process | DNA-binding transcription factor activity | regulation of establishment of protein localization | regulation of DNA-binding transcription factor activity | cellular macromolecule catabolic process | metabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | regulation of type B pancreatic cell development | peptidyl-lysine modification | regulation of secretion | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | gene expression | positive regulation of NF-kappaB transcription factor activity | regulation of protein secretion | cellular response to ionizing radiation | transcription, DNA-templated | ubiquitin-dependent protein catabolic process | negative regulation of cell cycle | organonitrogen compound catabolic process | regulation of cell communication | negative regulation of signal transduction | signaling | covalent chromatin modification | regulation of transcription, DNA-templated | internal protein amino acid acetylation | cellular protein metabolic process | cellular macromolecule biosynthetic process | regulation of developmental process | organelle organization | spermatogenesis | cellular protein modification process | regulation of transport | positive regulation of transcription, DNA-templated | regulation of hair cycle | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | photoperiodism | heterocycle metabolic process | positive regulation of metabolic process | chromosome organization | cellular metabolic process | regulation of protein localization | modification-dependent protein catabolic process | DNA damage checkpoint | cell cycle checkpoint | regulation of inflammatory response | response to redox state | sexual reproduction | response to ionizing radiation | signal transduction | regulation of signaling | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
chromosome | intracellular membrane-bounded organelle | cell | nuclear lumen | ribonucleoprotein granule | transcription factor complex | cytoplasm | intracellular organelle | protein-containing complex | nucleoplasm | ribonucleoprotein complex | membrane-bounded organelle | nucleus | organelle | cytoplasmic ribonucleoprotein granule | membrane-enclosed lumen | chromatoid body | cytosol | intracellular
