QuickView for CMH-1 (gene)

Gene Symbol:

CASP7 Homo sapiens

Full name:

caspase 7

Synonyms:

CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3, caspase-7, ICE-like apoptotic protease 3, apoptotic protease MCH-3, caspase 7, apoptosis-related cysteine peptidase, caspase 7, apoptosis-related cysteine protease

Genomic Location:

Chr 10: 115428925-115480654

Description:

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form...

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This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of the encoded protein is cleaved by caspase 3 and 10, is activated upon cell death stimuli and induces apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

IRF_Q6 ,  AATGTGA_MIR23A_MIR23B ,  IRF7_01 ,  ICSBP_Q6 ,  STTTCRNTTT_IRF_Q6

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-23 ,  Predicted Gene Targets for miR-323 ,  Predicted Gene Targets for miR-378

miRNA binding sites
(Source: miRecords):

hsa-miR-125b Targeted Genes

Cytogenetic Map:

10q25.3

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