QuickView for CMTDIB (gene)

Gene Symbol:

DNM2 Homo sapiens

Full name:

dynamin 2

Synonyms:

CMT2M, CMTDI1, CMTDIB, DI-CMTB, DYN2, DYNII, LCCS5, dynamin-2, dynamin II

Genomic Location:

Chr 19: 10689755-10803579

Description:

Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of th...

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Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Five alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

RYTTCCTG_ETS2_B ,  AAAGGGA_MIR204_MIR211 ,  ZF5_01 ,  GGGACCA_MIR133A_MIR133B ,  TTGCACT_MIR130A_MIR301_MIR130B ,  TATAAA_TATA_01 ,  CCAWYNNGAAR_UNKNOWN ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  GGGCGGR_SP1_Q6 ,  TGTYNNNNNRGCARM_UNKNOWN ,  GTGCCTT_MIR506 ,  TGCACTT_MIR519C_MIR519B_MIR519A ,  TBP_01 ,  CACTTTG_MIR520G_MIR520H

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-130 ,  Predicted Gene Targets for miR-133 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-204 ,  Predicted Gene Targets for miR-124a

miRNA binding sites
(Source: miRecords):

hsa-miR-124 Targeted Genes

Cytogenetic Map:

19p13.2

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