QuickView for CNOT4;jsessionid=0D9678E35C2B6DA45CC5B3FC6E3569B0 (gene)
- Gene Symbol:
- CNOT4
Homo sapiens - Full name:
- CCR4-NOT transcription complex subunit 4
- Synonyms:
- CLONE243, NOT4, NOT4H, CCR4-NOT transcription complex subunit 4, CCR4-associated factor 4, E3 ubiquitin-protein ligase CNOT4, NOT4 (negative regulator of transcription 4, yeast) homolog, RING-type E3 ubiquitin transferase CNOT4, potential transcriptional repressor NOT4Hp
- Genomic Location:
- Chr 7: 134697089-134845391
- Description:
-
The protein encoded by this gene is a subunit of the CCR4-NOT complex, a global transcriptional regulator. The encoded protein interacts with CNOT1 and has E3 ubiquitin ligase activity. Several transcript variants encoding different isoforms have been found for this gene.
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
7q33
| Transcripts Names |
|---|
| NM_001008225 |
| NM_013316 |
| NM_001190850 |
| NM_001190849 |
| NM_001190847 |
| NM_001190848 |
| XM_024446772 |
| XM_017012235 |
| Protein Names |
|---|
| E7ET38 |
| F8VQP3 |
| Q8IYM7 |
| Q8NCL0 |
| A0A024R776 |
| O95339 |
| A0A024R785 |
| A0A024R781 |
| Q9NPQ1 |
| O95627 |
| O95628 |
| Q9NZN6 |
GO Molecular Function
cation binding | nucleic acid binding | catalytic activity | ubiquitin-like protein transferase activity | ion binding | organic cyclic compound binding | protein binding | ubiquitin-protein transferase activity | transferase activity | metal ion binding | heterocyclic compound binding | RNA binding
GO Biological Process
RNA metabolic process | regulation of cell cycle process | intracellular signal transduction | proteolysis | regulation of cell cycle G1/S phase transition | regulation of immune system process | negative regulation of cellular process | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | regulation of G1/S transition of mitotic cell cycle | cellular process | organic substance catabolic process | proteolysis involved in cellular protein catabolic process | mitotic DNA integrity checkpoint | negative regulation of G1/S transition of mitotic cell cycle | regulation of megakaryocyte differentiation | regulation of cell cycle | regulation of myeloid cell differentiation | regulation of cell differentiation | regulation of cellular process | regulation of metabolic process | catabolic process | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | signal transduction involved in mitotic DNA damage checkpoint | mRNA catabolic process | response to stimulus | regulation of mitotic cell cycle phase transition | response to stress | regulation of cell cycle phase transition | cellular protein catabolic process | cellular nitrogen compound metabolic process | negative regulation of metabolic process | protein modification process | mRNA metabolic process | nuclear-transcribed mRNA catabolic process | macromolecule modification | nucleobase-containing compound catabolic process | nitrogen compound metabolic process | negative regulation of mitotic cell cycle phase transition | DNA damage response, signal transduction by p53 class mediator | mitotic DNA damage checkpoint | cellular response to DNA damage stimulus | positive regulation of cell cycle | signal transduction in response to DNA damage | regulation of gene expression | cellular response to stress | cell cycle | protein catabolic process | RNA catabolic process | regulation of cell cycle arrest | protein modification by small protein conjugation | nuclear-transcribed mRNA poly(A) tail shortening | signal transduction involved in cell cycle checkpoint | mitotic G1 DNA damage checkpoint | cell communication | aromatic compound catabolic process | regulation of mitotic cell cycle | positive regulation of cell cycle arrest | protein metabolic process | protein ubiquitination | G1 DNA damage checkpoint | regulation of hemopoiesis | cellular macromolecule catabolic process | protein autoubiquitination | mitotic cell cycle | metabolic process | ubiquitin-protein transferase activity | negative regulation of mitotic cell cycle | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of gene expression | signal transduction involved in mitotic cell cycle checkpoint | protein modification by small protein conjugation or removal | ubiquitin-dependent protein catabolic process | negative regulation of cell cycle | organonitrogen compound catabolic process | negative regulation of cell cycle G1/S phase transition | signaling | cellular protein metabolic process | signal transduction involved in DNA damage checkpoint | regulation of developmental process | positive regulation of cell cycle process | cellular protein modification process | mitotic G1/S transition checkpoint | heterocycle metabolic process | signal transduction involved in mitotic G1 DNA damage checkpoint | mitotic cell cycle checkpoint | cellular metabolic process | negative regulation of cell cycle process | modification-dependent protein catabolic process | DNA damage checkpoint | cell cycle checkpoint | signal transduction by p53 class mediator | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | signal transduction | macromolecule metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | cell | cytoplasm | intracellular organelle | protein-containing complex | membrane-bounded organelle | nucleus | organelle | CCR4-NOT complex | cytosol | intracellular
